ATP6V0C Products

Description

ATP6V0C encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the V0 domain. This gene had the previous symbols of ATP6C and ATP6L. [provided by RefSeq]

Bioinformatics

Entrez	527 Human
Uniprot	NM_001694 Human NP_001685.1 Human P27449 Human
Product By Gene ID	527
Alternate Names	ATP6CATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD ATP6LVPPC ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c ATPL H(+)-transporting two-sector ATPase, 16 kDa subunit vacuolar ATP synthase 16 kDa proteolipid subunit vacuolar H+ ATPase proton channel subunit Vacuolar proton pump 16 kDa proteolipid subunit VATL V-ATPase 16 kDa proteolipid subunit Vma3 V-type proton ATPase 16 kDa proteolipid subunit