ATF1 Products

Antibodies
ATF1 Antibody (2B4)
ATF1 Antibody (2B4)
NBP2-46552
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
ATF1 Antibody
ATF1 Antibody
H00000466-D01P
Species: Hu, Mu, Rt
Applications: WB, ELISA
Host: Rabbit Polyclonal
ATF1 Antibody
ATF1 Antibody
AF4370
Species: Hu, Mu
Applications: WB
Host: Goat Polyclonal
Antibody Pairs
ATF1 Antibody Pair
ATF1 Antibody Pair
H00000466-AP11
Species: Hu
Applications: S-ELISA
Lysates
ATF1 Overexpression Lysate (N ...
ATF1 Overexpression Lysate (Native)
NBL1-07787
Applications: WB
ATF1 Overexpression Lysate (D ...
ATF1 Overexpression Lysate (Denatu...
H00000466-T01
Applications: WB
Proteins
ATF1 Recombinant Protein Anti ...
ATF1 Recombinant Protein Antigen
NBP2-38747PEP
Species: Hu
Applications: AC
ATF1 Recombinant Protein
ATF1 Recombinant Protein
NBP1-78873
Species: Hu
Applications: PAGE
RNAi
ATF1 RNAi
ATF1 RNAi
H00000466-R01V
Species: Hu
Applications: WB, RNAi SP
ATF1 RNAi
ATF1 RNAi
H00000466-R01
Species: Hu

Description

ATF2 (Activating Transcription Factor 2, CREBP, HB16, CREB2, TREB7) is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 466
Alternate Names
  • EWS-ATF1
  • Protein TREB36
  • cAMP-dependent transcription factor ATF-1
  • TREB36cyclic AMP-dependent transcription factor ATF-1
  • activating transcription factor 1FUS/ATF-1

Research Areas for ATF1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific

Bioinformatics Tool for ATF1

Discover related pathways, diseases and genes to ATF1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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