ASK1 Products

Antibodies
ASK1 Antibody
ASK1 Antibody
NB100-56077
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
ASK1 Antibody (2E4)
ASK1 Antibody (2E4)
NBP2-37592
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
ASK1 Antibody [Unconjugated]
ASK1 Antibody [Unconjugated]
AF3575
Species: Hu
Applications: WB, ICC
Host: Sheep Polyclonal
Lysates
ASK1 Overexpression Lysate (D ...
ASK1 Overexpression Lysate (Denatu...
H00004217-T01
Species: Hu
Applications: WB
ASK1 Overexpression Lysate (N ...
ASK1 Overexpression Lysate (Native)
NBL1-12856
Applications: WB
Proteins
ASK1 [p Ser83] Peptide
ASK1 [p Ser83] Peptide
NBP1-96993
Applications: WB, ELISA, IP
ASK1 Peptide
ASK1 Peptide
NBP1-96992
Applications: WB, ELISA, IP
ASK1 Recombinant Protein
ASK1 Recombinant Protein
P4194
Species: Hu
Applications: Func, PAGE
RNAi
ASK1 RNAi
ASK1 RNAi
H00004217-R03
Species: Hu

Description

Apoptosis signal-regulating kinase-1 (ASK1, MEKK5, MAPKKK5) is a MAP3k type protein kinase belonging to mitogen-activated protein kinase kinase kinase (MAPKKK) family. As a regulator of JNK and p38 MAPK signaling pathways, ASK1/MEKK5 phosphorylates MMK4 to activate c-Jun N-terminal kinase (JNK) and phosphorylates MEK3 and MKK6 to activate p38. ASK1/MEKK5 is activated by oxidative stress, TNF via TRAF2, Fas via Daxx, calcium overload, and endoplasmic reticulum stress (1). ASK1/MEKK5 is inactivated by Trx, Grx, 14-3-3, and protein serine/threonine phosphatase 5 (2). While elevated level of ASK1/MEKK5 can induce apoptosis, a catalytically inactive ASK1/MEKK5 acts as an inhibitor in TNF-alpha induced apoptosis. Over-expression of ASK1/MEKK5 has also been implicated in cell differentiation, such as in keratinocyte differentiation through p38 pathway (3). ASK1/MEKK5 has been implicated as a therapeutic target for neurodegenerative disorder sand cardiac dysfunction (4).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 4217
Alternate Names
  • MAPK/ERK kinase kinase 5
  • EC 2.7.11
  • ASK-1
  • MAP/ERK kinase kinase 5
  • Apoptosis signal-regulating kinase 1
  • MEKK5apoptosis signal regulating kinase 1
  • MAPKKK5EC 2.7.11.25
  • ASK1MEKK 5
  • MEK kinase 5
  • mitogen-activated protein kinase kinase kinase 5

Research Areas for ASK1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Phospho-Specific
Protein Kinase

Bioinformatics Tool for ASK1

Discover related pathways, diseases and genes to ASK1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related ASK1 Blog Posts

Check out the latest blog posts on ASK1.
IRE1 alpha dependent apoptotic-signaling pathway
Despite in depth characterization of the role of IRE1 alpha (inositol-requiring enzyme 1 alpha) in activating the unfolded protein response (UPR) in the ER - little is known about the molecular mechanisms by which this ER protein has shown to reg...    Read more.
Read more ASK1 related blogs.