ARFIP1 Products

Antibodies
ARFIP1 Antibody
ARFIP1 Antibody
NBP2-38342
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
ARFIP1 Antibody
ARFIP1 Antibody
NBP2-39002
Species: Hu, Mouse
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
ARFIP1 Antibody (1F10)
ARFIP1 Antibody (1F10)
H00027236-M05
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
ARFIP1 Overexpression Lysate ...
ARFIP1 Overexpression Lysate (Native)
NBP2-07334
Applications: WB
ARFIP1 Overexpression Lysate ...
ARFIP1 Overexpression Lysate (Native)
NBL1-07658
Applications: WB
ARFIP1 Overexpression Lysate ...
ARFIP1 Overexpression Lysate (Dena...
H00027236-T01
Applications: WB
Proteins
ARFIP1 Recombinant Protein An ...
ARFIP1 Recombinant Protein Antigen
NBP2-38342PEP
Species: Hu
Applications: AC
ARFIP1 Recombinant Protein An ...
ARFIP1 Recombinant Protein Antigen
NBP2-39002PEP
Species: Hu
Applications: AC
ARFIP1 Recombinant Protein
ARFIP1 Recombinant Protein
NBP2-51834
Species: Hu
Applications: PAGE

Description

ADP-ribosylation factors, or ARFs, enhance the ADP ribosyltransferase activity of cholera toxin and are implicated in vesicle transport between endoplasmic reticulum and the Golgi complex. Arfaptin 1 is recruited from the cytosol to Golgi membranes by ARFs in a guanosine 5'-O-(3-thiotriphosphate)-dependent and brefeldin A-sensitive manner but is not a constituent of coatomer. Arfaptin 1 binds to nonmyristoylated GTP-bound ARF3, but not to GDP-bound ARF3, and also to ARF1, another class I ARF. It binds with lower affinity to ARF5, a class II ARF, and with very little affinity to ARF6, a class III ARF. POR1 (also designated arfaptin 2) was first isolated as a Rac 1 binding protein necessary for Rac mediated Actin polymerization and the subsequent formation of membrane ruffles and lamellipodia. POR1 has also been shown to interact with the ADP ribosylation factor ARF6, a GTPase that associates with the plasma membrane and intracellular endosome vesicles, in a GTP dependent manner. The association of POR1 with ARF6 stimulates induction of Actin polymerization. POR1 appears to play a regulatory role through multiple signaling pathways in the reorganization of the cytoskeletal structure.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 27236
Alternate Names
  • arfaptin-1
  • arfaptin 1
  • MGC117369
  • ADP-ribosylation factor-interacting protein 1
  • HSU52521
  • ADP-ribosylation factor interacting protein 1

Diseases related to ARFIP1

Discover more about diseases related to ARFIP1.

Cholera
Fibrosarcoma
Neoplasm Metastasis
Malignant Neoplasms
Insulinoma
Stomatitis
Vesicular Stomatitis

Pathways for ARFIP1

View related products by pathway and learn more about each of the pathways below.

Transport
Secretion
Clathrin Coat Assembly
Secretory Pathway
Vesicle Transport
Glycosylation
Protein Transport
Localization

PTMs for ARFIP1

Learn more about PTMs related to ARFIP1.

Ribosylation
Myristoylation
Glycosylation

Bioinformatics Tool for ARFIP1

Discover related pathways, diseases and genes to ARFIP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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