Aquaporin-0 Products

Antibodies
Aquaporin-0 Antibody
Aquaporin-0 Antibody
NBP1-19776
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Aquaporin-0 Overexpression Ly ...
Aquaporin-0 Overexpression Lysate ...
NBP2-10364
Applications: WB
Proteins
Recombinant Human Aquaporin-0 ...
Recombinant Human Aquaporin-0 Protein
H00004284-G01-10ug
Species: Hu
RNAi
Aquaporin-0 RNAi
Aquaporin-0 RNAi
H00004284-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Aquaporins (AQPs) are a large family of integral membrane channel proteins that facilitate the transport of water through the cell membrane. Aquaporins are widely distributed and are involved in renal water absorption, generation of pulmonary secretions, lacrimation and the secretion and reabsorption of cerebrospinal fluid and aqueous humor. AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells where it functions not only as a water pore, but it is also involved in fiber-fiber adhesion and is crucial for fiber cell structure and organization. AQP0 contains an additional pore constriction, not seen in any other aquaporin structures, which may be responsible for pore gating. The closed AQP0 pore holds just three water molecules, which are spaced too far apart to form hydrogen bonds with each other. The C-terminal domain of AQP0 undergoes extensive post-translational modification, including many truncations, during lens aging due to the actions of m-Calpain, proteases or non-enzymatic mechanisms. These truncation sites may be involved in the development of cataracts.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Product By Gene ID 4284
Alternate Names
  • aquaporin 0
  • lens fiber major intrinsic protein
  • MP26
  • major intrinsic protein of lens fiber

Bioinformatics Tool for Aquaporin-0

Discover related pathways, diseases and genes to Aquaporin-0. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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