APBA3/Mint-3 Products

Antibodies
APBA3/Mint-3 Antibody
APBA3/Mint-3 Antibody
NBP1-92117
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
APBA3/Mint-3 Antibody
APBA3/Mint-3 Antibody
AF5689
Species: Hu
Applications: WB
Host: Sheep Polyclonal
APBA3/Mint-3 Antibody
APBA3/Mint-3 Antibody
NB120-3450
Species: Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Lysates
APBA3/Mint-3 Overexpression L ...
APBA3/Mint-3 Overexpression Lysate...
NBP2-10542
Applications: WB
Proteins
APBA3/Mint-3 Recombinant Prot ...
APBA3/Mint-3 Recombinant Protein A...
NBP1-92117PEP
Species: Hu
Applications: AC

Description

The munc-18 interacting (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three mint isoforms, Mint 1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint 1 and 2 appear to be expressed exclusively in the brain and are found to bind to munc-18, an essential component of the synaptic vesicle fusion machinery. Mint 3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that Mint 3 does not interact with munc-18. Mint 3 has been found to interact with the Alzheimer®s Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that Mint 3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer®s disease.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Product By Gene ID 9546
Alternate Names
  • Mint-3
  • MGC:15815
  • MINT3
  • Neuronal Munc18-1-interacting protein 3
  • X11-like 2 protein
  • Neuron-specific X11L2 protein
  • phosphotyrosine-binding/-interacting domain (PTB)-bearing protein
  • Adapter protein X11gamma
  • mint-3
  • mint3
  • X11L2amyloid beta A4 precursor protein-binding family A member 3
  • amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)
  • amyloid beta (A4) precursor protein-binding, family A, member 3

Research Areas for APBA3/Mint-3

Find related products by research area and learn more about each of the different research areas below.

Membrane Trafficking and Chaperones
Vision

PTMs for APBA3/Mint-3

Learn more about PTMs related to APBA3/Mint-3.

Methylation
Cleavage
Ribosylation
Phosphorylation

Bioinformatics Tool for APBA3/Mint-3

Discover related pathways, diseases and genes to APBA3/Mint-3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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