Anthrax PA Products


Description

Anthrax PA (Protective Antigen) and Anthrax LF (Lethal Factor), along with Anthrax EF (Edema Factor), are toxins produced by Bacillus anthracis. All three of the proteins must be present for toxic entry into cells. PA is secreted from Bacillus anthracis as an 83 kDa (PA83) protein which is cleaved by furin protease, releasing a 20 kDa fragment. The 63 kDa portion (PA63) of the cleavage product forms a heptamer, which binds the toxins LF and EF. This complex enters via receptor-mediated endocytosis where LF and EF exert their toxic effects.

Bioinformatics

Alternate Names
  • Bacillus anthracis protective antigen
  • Protective antigen
  • Paga
  • PAG
  • PA83
  • PA
  • PA 83
  • Anthrax toxins translocating protein
  • anthrax PA

Research Areas for Anthrax PA

Find related products by research area and learn more about each of the different research areas below.

Immunology
Virology, Bacteria and Parasites