Ancient ubiquitous protein 1 Products

Description

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signaling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.

Bioinformatics

Entrez	550 Human 11993 Mouse 680423 Rat
Uniprot	A1L134 Rat
Product By Gene ID	550
Alternate Names	ancient ubiquitous protein 1