Aminopeptidase PILS/ARTS1 Products

Antibodies
Aminopeptidase PILS/ARTS1 Ant ...
Aminopeptidase PILS/ARTS1 Antibody...
MAB2334
Species: Hu, Mu
Applications: WB, Simple Western
Host: Mouse Monoclonal
Aminopeptidase PILS/ARTS1 Ant ...
Aminopeptidase PILS/ARTS1 Antibody...
AF2334
Species: Hu
Applications: WB, IHC, IP, ICC
Host: Goat Polyclonal
Aminopeptidase PILS/ARTS1 Ant ...
Aminopeptidase PILS/ARTS1 Antibody
NB100-92405
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Aminopeptidase PILS/ARTS1 Ove ...
Aminopeptidase PILS/ARTS1 Overexpr...
NBP2-10627
Applications: WB
Aminopeptidase PILS/ARTS1 Ove ...
Aminopeptidase PILS/ARTS1 Overexpr...
NBP2-11195
Applications: WB
Aminopeptidase PILS/ARTS1 Ove ...
Aminopeptidase PILS/ARTS1 Overexpr...
NBP2-04355
Applications: WB
Proteins
Aminopeptidase PILS/ARTS1 Par ...
Aminopeptidase PILS/ARTS1 Partial ...
H00051752-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Aminopeptidase PILS/ARTS1 RNA ...
Aminopeptidase PILS/ARTS1 RNAi
H00051752-R01
Species: Hu

Description

The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is a 120 kDa protein localized to the lumen of the ER, which removes NH2-terminal residues from many antigenic precursors for MHC class I peptide presentation. Peptides that are presented by MHC class I on the surface of a cell must be 8-11 residues long, and ERAP1 specifically trims peptides of 9 amino acids or more. ERAP1 is also induced by interferon-gamma. The gene encoding human ERAP1 maps to chromosome 5q15. ERAP1 has previously been characterized as adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1). A-LAP is thought to inactivate several bioactive peptides, including angiotensin II and, subsequently, may be involved in the regulation of blood pressure. PILS-AP is described as playing a role in angiogenesis by regulating the proliferation and migration of endothelial cells, and ARTS-1 is characterized as a TNFR1 binding protein that promotes TNFR1 shedding. Further research will be necessary to fully elucidate the functions of this protein.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 51752
Alternate Names
  • EC 3.4.11.1
  • Puromycin-insensitive leucyl-specific aminopeptidase
  • EC 3.4.11
  • Aminopeptidase PILS
  • EC 3.4.11.-
  • Adipocyte-derived leucine aminopeptidase
  • endoplasmic reticulum aminopeptidase associated with antigen processing
  • ERAAP1
  • ARTS1aminopeptidase regulator of TNFR1 shedding
  • PILS-APERAAP
  • ARTS-1PILSAP
  • A-LAPALAP
  • KIAA0525APPILS
  • Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
  • endoplasmic reticulum aminopeptidase 1

PTMs for Aminopeptidase PILS/ARTS1

Learn more about PTMs related to Aminopeptidase PILS/ARTS1.

Cleavage
Methylation

Bioinformatics Tool for Aminopeptidase PILS/ARTS1

Discover related pathways, diseases and genes to Aminopeptidase PILS/ARTS1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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