Aly Products

Aly Antibody
Aly Antibody
Species: Hu, Mu, Bovine
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Aly Antibody
Aly Antibody
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Aly Antibody (11G5)
Aly Antibody (11G5)
Species: Hu, Xp
Applications: WB, ELISA, ICC/IF, IP, MiAr
Host: Mouse Monoclonal
Aly Partial Recombinant Prote ...
Aly Partial Recombinant Protein
Species: Hu
Applications: WB, ELISA, PA
Aly Recombinant Protein Antig ...
Aly Recombinant Protein Antigen
Species: Hu
Applications: B/N, Ctrl
Aly RNAi
Aly RNAi
Species: Hu


Pre-mRNA splicing plays an important role in regulation of gene expression. During the splicing process, specific proteins are recruited to the mRNA and assembled into a complex of mRNA-protein near the exon-exon junction. This complex is termed the mRNA-protein complex (mRNP) or the exon-exon junction complex. The proteins that are found in this complex include: Y14, magoh, Aly/REF, RNPS1, Upf3, and DEK.1-5 Aly (also known as mREF1-I) is the mammalian homologue of the yeast mRNA export factor Yra1p.6-7 It is a 233 amino acid RNAbinding protein that contains a RNA-binding domain and is recruited to the mRNP complexes during the splicing. Excess of recombinant expression of Aly in the cells increases both the rate and efficiency of spliced and unspliced mRNA export (in vivo) from the nucleus to the cytoplasm. In contrast to the Y14 protein, Aly is dissociated from the mRNAs after the export to the cytoplasm.1, 5-6


Entrez Human
Uniprot Human
Product By Gene ID 10189
Alternate Names
  • Transcriptional coactivator Aly/REF
  • Tho4
  • Ally of AML-1 and LEF-1
  • tho4
  • REF
  • THO complex subunit 4
  • ALYBEFbZIP enhancing factor
  • bZIP-enhancing factor BEF
  • THO complex 4

PTMs for Aly

Learn more about PTMs related to Aly.


Bioinformatics Tool for Aly

Discover related pathways, diseases and genes to Aly. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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