Applications: WB, IHC, IF
Host: Mouse monoclonal
Species: Hu, Mu
Applications: WB, Simple Western
Host: Goat Polyclonal
WB, ELISA, ICC/IFHost:
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products--alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander®s disease where it accumulates in brain cells of those afflicted.
|Product By Gene ID
- human alphaA-crystallin (CRYA1), 10HspB4
- CRYA1crystallin, alpha-1
- HSPB4alpha-crystallin A chain
- Heat shock protein beta-4
- crystallin, alpha A
Bioinformatics Tool for AlphaA Crystallin/CRYAA
Discover related pathways, diseases and genes to AlphaA Crystallin/CRYAA. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.