AlphaA Crystallin/CRYAA Products

Antibodies
AlphaA Crystallin/CRYAA Antib ...
AlphaA Crystallin/CRYAA Antibody (...
Species: Hu
Applications: WB, IHC, IF
Host: Mouse monoclonal
AlphaA Crystallin/CRYAA Antib ...
AlphaA Crystallin/CRYAA Antibody [...
AF4848
Species: Hu, Mu
Applications: WB, Simple Western
Host: Goat Polyclonal
AlphaA Crystallin/CRYAA Antib ...
AlphaA Crystallin/CRYAA Antibody (...
NBP2-12875
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Lysates
AlphaA Crystallin/CRYAA Overe ...
AlphaA Crystallin/CRYAA Overexpres...
NBP2-10665
Applications: WB
Proteins
AlphaA Crystallin/CRYAA Recom ...
AlphaA Crystallin/CRYAA Recombinan...
NBP2-55161PEP
Species: Hu
Applications: B/N, Ctrl
Recombinant Human AlphaA Crys ...
Recombinant Human AlphaA Crystalli...
NBC1-18351
Species: Hu
Applications: PAGE

Description

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products--alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander®s disease where it accumulates in brain cells of those afflicted.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Product By Gene ID 1409
Alternate Names
  • human alphaA-crystallin (CRYA1), 10HspB4
  • CRYA1crystallin, alpha-1
  • HSPB4alpha-crystallin A chain
  • Heat shock protein beta-4
  • crystallin, alpha A

Research Areas for AlphaA Crystallin/CRYAA

Find related products by research area and learn more about each of the different research areas below.

Membrane Trafficking and Chaperones
Vision

PTMs for AlphaA Crystallin/CRYAA

Learn more about PTMs related to AlphaA Crystallin/CRYAA.

Phosphorylation
Demethylation
Methylation
Deamidation

Bioinformatics Tool for AlphaA Crystallin/CRYAA

Discover related pathways, diseases and genes to AlphaA Crystallin/CRYAA. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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