Aldolase B Products

Description

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13 ) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.

Bioinformatics

Entrez	229 Human 24190 Rat
Uniprot	AAH29399 Human NM_000035 Human NP_000026 Human NP_000026.2 Human P05062 Human
Product By Gene ID	229
Alternate Names	ALDO2 aldolase B, fructose-bisphosphate EC 4.1.2.13 fructose-bisphosphatase fructose-bisphosphate aldolase B

Research Areas for Aldolase B

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Cancer