AKAP12 Products

Description

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Bioinformatics

Entrez	9590 Human
Uniprot	NM_144497 Human NP_005091 Human Q02952 Human
Product By Gene ID	9590
Alternate Names	A kinase (PRKA) anchor protein (gravin) 12 A kinase (PRKA) anchor protein 12 AKAP 250 AKAP250250kDa DKFZp686M0430 DKFZp686O0331 FLJ20945 FLJ97621 Gravin kinase scaffold protein gravin myasthenia gravis autoantigen gravin Myasthenia gravis autoantigen

Research Areas for AKAP12

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Signal Transduction