AGPAT2 Products

Description

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]

Bioinformatics

Entrez	10555 Human
Uniprot	NP_006403.2 Human
Product By Gene ID	10555
Alternate Names	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acidacyltransferase, beta) 1-acylglycerol-3-phosphate O-acyltransferase 2 1-AGPAT 2,1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acidacyltransferase-beta) 1-AGPAT2,1-AGP acyltransferase 2,1-acyl-sn-glycerol-3-phosphate acyltransferase beta Berardinelli-Seip congenital lipodystrophy BSCL BSCL1 EC 2.3.1.51 LPAAB LPAAT-beta Lysophosphatidic acid acyltransferase beta lysophosphatidic acid acyltransferase-beta

Research Areas for AGPAT2

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Cancer
Cardiovascular Biology