5-HT1B Products

Description

Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. The in situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.

Bioinformatics

Entrez	3351 Human 15551 Mouse 25075 Rat
Uniprot	P28222 P28334 Mouse P28564 Rat
Product By Gene ID	3351
Alternate Names	5HT1B 5-HT1B 5-HT1B5-HT-1B 5HT1DB 5-HT1DB 5-hydroxytryptamine (serotonin) receptor 1B HTR1B HTR1D2 HTR1D2,5-hydroxytryptamine receptor 1B HTR1DB S12 S125-HT-1D-beta Serotonin 1D beta receptor Serotonin receptor 1B

Research Areas for 5-HT1B

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GPCR