BNIP3L Products

Description

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growingsubclass of the Bcl-2 family. A novel BH3 domaincontaining protein was recently identified and designated Bnip3L, Bnip3a, and Nix (for Nip3-like protein X) (Matsushima, M. et al.; Yasuda, M. et al.; Chen, G, et al.).Bnip3L/Bnip3a/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Over expression of Bnip3L induces apoptosis (Yasuda, M. et al.; Chen, G, et al.). Bnip3L interacts withand overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3Lis localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues (Matsushima, M. et al.; Yasuda, M. et al.). Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.

Bioinformatics

Entrez	12177 Mouse 534615 Bovine 665 Human
Uniprot	AF067396 Human NM_004331 Human NP_004322 Human NP_004322.1 Human O60238 Human
Product By Gene ID	665
Alternate Names	Adenovirus E1B19K-binding protein B5 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like BCL2/adenovirus E1B 19-kd protein-interacting protein 3a BCL2/adenovirus E1B 19kDa interacting protein 3-like BNIP3a BNIP3A BNIP3H NIP3L NIP3-like protein X Nix NIXBCL2/adenovirus E1B 19kD-interacting protein 3-like

Research Areas for BNIP3L

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Hypoxia
p53 Pathway

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