Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: Flow, ICC/IF, IP, WB (-)
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: AC
Description
The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML) (1-2). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42 (3). Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling (4).
Bioinformatics
| Product By Gene ID |
613 |
| Alternate Names |
- ALL
- ALLD22S11
- BCR
- BCR1
- breakpoint cluster region protein
- breakpoint cluster region
- CMLEC 2.7.11.1
- D22S662
- PHL
- PHLFLJ16453
- Renal carcinoma antigen NY-REN-26
|
