SODD/BAG4 Products

Description

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

Bioinformatics

Entrez	361167 Rat 545156 Mouse 67384 Mouse 84009 Rat 9530 Human
Uniprot	AAH38505 Human AF111116 Human NM_004874 Human NP_004865 Human NP_004865.1 Human O95429 Human
Product By Gene ID	9530
Alternate Names	BAG-4 BAG-family molecular chaperone regulator-4 Bcl-2-associated athanogene 4 BCL2-associated athanogene 4 Silencer of death domains SODDBAG family molecular chaperone regulator 4

Research Areas for SODD/BAG4

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors