SODD/BAG4 Products

Description

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. [provided by RefSeq]

Bioinformatics

Entrez	9530 Human
Uniprot	AAH38505 Human
Product By Gene ID	9530
Alternate Names	BAG4 BAG-4 BAG-family molecular chaperone regulator-4 Bcl-2-associated athanogene 4 BCL2-associated athanogene 4 Silencer of death domains SODD SODDBAG family molecular chaperone regulator 4

Research Areas for SODD/BAG4

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Apoptosis