SLC34A1 encodes the 69 kDa sodium-dependent phosphate transport protein 2A (Npt2a). SLC34A is a member of the type II sodium-phosphate co-transporter family, along with SLC34A3 which encodes Npt2c. These proteins are abundantly expressed along the proximal tubules of the kidneys where most of the filtered inorganic phosphate (Pi) is reabsorbed into the body. Renal reabsorption of Pi directly regulates blood phosphate levels, important for many metabolic processes.
