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Sjogren’s syndrome

Trex1 (3'-5' exonuclease TREX1, DNase III)

This gene encodes the major 3' to 5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that appears to provide proofreading for checkpoint signaling after DNA damage in response to oxidative stress and apoptosis. It is ubiquitously expressed. Trex1 binds to single-stranded DNA coated with replication protein A found at sites of DNA damage, and recruits the ataxia telangiectasia and Rad3 related protein (ATR) checkpoint kinase.

Tags: 
ataxia telangiectasia
Rad3 related protein
Aicardi-Goutieres
SLE
Sjogren’s syndrome
trex1 antibody
AP-1
Trex1