The integral endoplasmic reticulum membrane-based enzyme G6PC hydrolyzes its substrate glucose-6-phosphate into glucose. Specifically, G6PC breaks down D-glucose 6-phosphate to D-glucose and orthophosphate. Because G6PC forms with the glucose-6-phosphate transporter (SLC37A4/G6PT), the resulting complex is responsible for glucose production. Thus, G6PC is the key enzyme in glucose homeostasis, functioning in both the processes of gluconeogenesis and glycogenolysis.
