cofilin

Actin is the widely studied and ubiquitous cytoskeletal protein capable of forming dynamic microfilament structures. These filaments are essential for diverse cellular functions including cell shape, migration, cytokinesis, and intracellular trafficking (1). Actin is present in three main isoforms: alpha, beta, and gamma. These globular actin isoforms (G-actin) assemble into dynamic filamentous polymers called F-actin. This process is highly regulated by various actin-binding proteins that affect the stability, organization, and depolymerization of F-actin (1).