cathepsin B antibody

Cathepsins are a family of lysosomal proteases (serine, aspartic and cysteine proteases) that acts in conjunction with lipases and nucleases to degrade biological macromolecules in the lysosomes (1). While most cathepsins are ubiquitously expressed to support normal lysosomal degradation, cathepsin B is unique for its role in various pathologies and malignancies (2). Cathepsin B is often overexpressed and alternatively spliced in cancer cells (2).