alpha adducing

The structure and organization of the plasma membrane is maintained by an underlying network of cytoskeletal proteins including actin and spectrin. Adducin, a member of this protein network, binds to bundles and caps actin filaments and links them to spectrin. Adducin’s role in organizing the cytoskeletal meshwork at the plasma membrane is important in signal transduction, cell-cell adhesion, and cell migration (1).