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actin antibodies

Alpha-actin/ACTA1 - A skeletal muscle isoform mutated in various myopathies

Actin is an abundant cytoskeletal protein involved in a variety of cellular processes such as cell motility, cell division, and muscle contraction. Actin monomers assemble into filaments and can provide a track for transport of cargo by the molecular motor myosin (1). Alternatively, interaction with myosin allows contraction between actin filaments. This contractility is essential during cell migration and cytokinesis (1). On a larger scale, organized scaffolds of actin filaments interact with myosin to provide mechanical force during muscle contraction (1).