IRE1 antibody

During cellular stress the protein folding capacity of the ER is diminished. In order to maintain homeostasis and ensure proper protein folding cells activate the unfolded protein response (UPR), a signaling network consisting of sensors and effectors to enhance the chaperone activity of the cell, increase degradation of accumulated proteins, and/or trigger apoptosis.  Inositol-requiring enzyme 1 (IRE1), an ER-transmembrane protein, is an essential component of the UPR pathway important for sensing and responding to ER stress.

IRE1 resides in the endoplasmic reticulum (ER) as a transmembrane protein with both serine-threonine kinase and endoribonuclease activities. It acts as an unfolded protein response (UPR) sensor through XBP1 transcriptional activation and has been found to have many physiological functions due to the fundamental importance of protein folding.