FOXO1A

The mammalian forkhead O class transcription factors (FOXO) regulate diverse cellular processes such as metabolism, cell cycle, and apoptosis. Activity of these transcription factors can be regulated by diverse post-translational modifications including phosphorylation, acetylation, and ubiquitination (1). These modifications can alter nuclear transport, DNA binding, and protein-protein interactions to alter transcriptional activity. The best studied member of the FOXO family is FOXO1.

Orthologs are one of the classes of homolog genes. They occur in different species, but are linked by a common ancestral pathway. During evolution, they retain the same original function, irrespective of the species. Among the orthologs covered on our antibody databaseare those of the Forkhead Transcription Factor (FOX) superfamily of proteins.