Human Monoclonal IgM+IgD+ B Cell Line Announced by Novus Biologicals

Novus Biologicals announced today a new CL-01 Cell Line.

The CL-01 cell line (Catalog Number NBP1-49595) is the only non-antigen specific human monoclonal B cell line that expresses surface IgM and IgD, and therefore readily differentiates upon appropriate stimuli. This characteristic makes the CL-01 cell line an ideal model system for in vitro studies of human B cell differentiation with implications on drug development for cancer, autoimmune and infectious diseases.

CL-01 cells can undergo somatic hypermutation, Ig class switch to all seven downstream isotypes, and complete plasmacytoid phenotypic differentiation in vitro. Compared to all polyclonal cells used previously, CL-01 cells are available in a large amount, are homogenous in genetic makeup and are able to achieve higher switching efficiency.

Novus Biologicals provides additional cell lines, including: DGCR8 knockout mouse embryonic stem cells (catalog number NBA1-19349) and v6.5 mouse embryonic stem cells (catalog number NBP1-41162). For more information on cell lines or to inquire about product collaborations, please contact the Novus Product Development Team by calling 303-730-1950 or via e-mail at

About Novus Biologicals (

Novus Biologicals is a biotechnology company whose mission is to accelerate scientific discovery by developing and marketing unique products in the forefront of science.  Novus Biologicals provides primary antibodies, secondary antibodies, conjugated antibodies, proteins, peptides, isotype and loading controls, RNAi, lysates, stem cell lines and antibody labeling kits to the bioscience community.  All of Novus' products are 100% guaranteed to work in the species and applications listed on the datasheet.  By serving niche and emerging markets, Novus Biologicals has formed and will continue to form ongoing partnerships with leading researchers.


Release Date: 
Friday, February 25, 2011 - 07:00