Description
CL-01 cell line is the only non-antigen specific human monoclonal B cell line that expresses surface IgM and IgD, therefore ready to differentiate upon appropriate stimuli. CL-01 cells are physiological stimuli inducible and can display the phenotypic changes putatively attributed to B cells during maturation. CL-01 cells can undergo somatic hypermutation, Ig class switching and complete differentiation in vitro. Compared to previously used polyclonal cells, CL-01 cells are available in large amounts; they are homogenous in genetic makeup and achieve higher switching efficiency. These features make the CL-01 cell line an ideal model system for in vitro studies of human B cell differentiation and for cancer, autoimmune, and infectious diseases drug development.
Bioinformatics
| Alternate Names |
- CL01 cell line
- CL01 cells
- CL-01 cells
- Human Monoclonal IgM+IgD+ B Cell Line
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