Neurodegeneration

Neurodegeneration is a broad term that refers to any process that causes damage to the neurons of the brain or spinal cord. When a neuronal population is compromised, it is atypical for the neurons to regenerate themselves, leading to neurodegenerative disease. The study of neurodegeneration aims to unfold the mechanisms behind neurodegeneration and subsequent disease. This month, we are highlighting our top selling primary antibodies related to Alzheimer's, Huntington's and Parkinson's disease. Additionally, we have focused on a controversial mechanism of neuronal toxicity mitochondrial oxidative stress. Also included are a brief list of popular neuronal markers to further validate your experimental results.

New to Novus are our neural progenitor stem cells and cortical neurons. The opportunity to study neurodegeneration on a vigorously tested in vitro cell model is priceless. Our Human Neural Progenitor cells (hNPCs) are capable of generating cortical neurons that are electrically active and have proven synapse formation. If you are studying Alzheimer's disease specifically, be sure to browse through our Alzheimer's Disease Neural Progenitor cells. These human iPS cell derived AD hNPCs provide a more approachable platform for conducting your research. What's more, our cortical neurons are available both fresh and frozen in order to fit your experimental needs. For more information regarding our new stem cells, please contact amelia@novusbio.com.

Don't forget to request or download an Alzheimer's Pathway Poster and stop by Laverne's lab bench to learn more about the powerful Novus Explorer tool.

 

Antibodies for Alzheimer's Research
Antibody Catalog # Host Clonality Species Application
Presenilin 1 NB100-74510 Ms Monoclonal Hu, Ms, Rt, Mk WB, ELISA, ICC, IHC, IHC-P, IP
NLRP2 NB100-56155 Rb Polyclonal Hu WB, IHC, IHC-P, IP
ApoE NB110-60531 Ms Monoclonal Hu, Ms, Rt (negative) WB, ELISA, IHC, IP
SLC6A3 NBP2-22164 Ms Monoclonal Ms, Rt, Ca, Hu (negative) WB, ELISA, ICC, IHC, IHC-P, IP
Tau NB110-57615 Rb Monoclonal Hu, Ms, Rt, Ca WB, ICC, IHC, IHC-P, IP
TNF alpha NBP2-27224 Ms Monoclonal Hu WB, B/N, FLOW
Browse through our complete list of Alzheimer’s related antibodies here.

 

 

 

Antibodies for Parkinson's Research
Antibody Catalog # Host Clonality Species Application
Pink-1 BC100-494 Rb Polyclonal Hu, Ms WB, ICC, IHC, IP, PEP-ELISA
PARKIN NB100-91921 Rb Polyclonal Hu, Ms, Rt WB, ICC, IHC, IHC-P
DJ-1 NB300-270 Rb Polyclonal Hu, Ms, Ck WB, ICC, IP, in vitro
alpha-synuclein NBP1-26380 Ms Monoclonal Hu, Ms WB, ICC, IHC, IHC-Fr, IHC-P
LRRK2 NB300-268 Rb Polyclonal Hu, Ms, Bv, Ce WB, ICC, IHC, IHC-Fr, IHC-P, IP
Tyrosine Hydroxylase NB300-109 Rb Polyclonal Hu, Ms, Rt, Dr WB, ICC, IHC, IHC-Fr, IHC-P
Browse through our complete list of Parkinson’s related antibodies here.

 

 

 

 

Antibodies for Huntington's Research
Antibody Catalog # Host Clonality Species Application
BDNF NB100-98682 Rb Polyclonal Hu, Ms, Rt WB, ICC, IHC, IHC-Fr, IHC-P
HTT NBP1-03377 Rb Polyclonal Ms, Rt WB, ICC, IHC, IHC-Fr, IHC-P
CREB NB100-410 Ck Polyclonal Hu, Ms, Rt WB, ICC, IHC, IHC-P
SOD1 NBP1-31204 Rb Polyclonal Hu, Ms, Rt WB, DB, ICC, IHC, IHC-P
Nrf2 NB100-80012 Rb Monoclonal Hu, Ms (negative), Rat (negative) WB, FLOW, ICC, IHC, IHC-P, IP
HAP1 NB110-74569 Ms Monoclonal Hu, Ms, Rt WB, ICC, IHC, IHC-Fr, IHC-P, IP

 

 

 

 

Antibodies for Mitochondrial Oxidative Stress Research
Antibody Catalog # Host Clonality Species Application
PUMA NB500-261 Rb Polyclonal Hu WB, ICC
NfkB NB100-56712 Ms Monoclonal Hu, Ms, Rt WB, FLOW, IHC, IHC-P
OPA-1 NB110-55290 Rb Polyclonal Hu, Ms, Rt, Ck WB, IHC, IHC-P
Drp-1 NB110-55237 Rb Polyclonal Hu, Ms, Rt WB, ICC, IHC, IHC-P
p53 NB200-103 Ms Monoclonal Hu, Ms, Rt, Ye, Xp WB, ELISA, FLOW, ICC, IHC, IHC-Fr, IHC-P
Caspase 3 NB500-210 Ms Monoclonal Hu, Ms, Rt WB, IHC, IHC-P
Browse through our complete list of Mitochondrial related antibodies here.

 

 

 

 

Neuronal Marker Antibodies
Antibody Catalog # Host Clonality Species Application
GFAP NB300-141 Rb Polyclonal Hu, Ms, Rt, Bv, Ca, Ck, Gp, Po, Fe WB, ICC, IHC, IHC-Fr, IHC-P
NeuN NBP1-77686 Rb Polyclonal Hu, Ms, Rt ICC, IHC, IHC-P
NSE NB100-1606 Ck Polyclonal Hu, Ms, Rt WB, ICC, IHC, IHC-P
Beta Tubulin 3 NBP1-42568 Ms Monoclonal Hu WB, ELISA, FLOW, ICC
Vimentin NB300-223 Ck Polyclonal Hu, Ms, Rt WB, ICC, IHC, IHC-P
Tyrosine Hydroxylase NB300-109 Rb Polyclonal Hu, Ms, Rt, Dr WB, ICC, IHC, IHC-Fr, IHC-P
Browse through our complete list of Neuronal Marker Antibodies here.

 

 

 

 

Neuronal Stem Cells and Cortical Neurons
Product Description Variety Origin
Human Neural Progenitor Cells 5 Male/Female donors Cord Blood CD34+ Cells
Human Cerebral Cortical Neurons (Frozen) 5 Male/Female donors Cord Blood CD34+ Cells
Human Cerebral Cortical Neurons (Fresh) 5 Male/Female donors Cord Blood CD34+ Cells
Alzheimer's Disease Human Neural Progenitor Cells 5 Male/Female donors Dermal Fibroblasts
Neural Maintenance Media *more media enhancers coming soon  
Visit our dedicated Neural Stem cell product page here.