Methylation is one of many types of post-translational modifications (PTMs) and is particularly important in epigenetics research today. Methylation occurs when a protein is post-translationally modified via attachment of one or more methyl groups. There are two different types of methylation: N-methylation and O-methylation. N-methylation, an irreversible reaction, occurs when a methyl group is transferred to nitrogen on an amino acid residue. O-methylation, a potentially reversible reaction, occurs when a methyl group is transferred to oxygen on an amino acid residue. Methylation of proteins usually takes place on lysine residues or argenine residues. While lysine may be methylated up to three times, argenine may only be methylated once or twice. Methylation of histone proteins is one of the most common type of methylation PTMs. Histone methylation is catalyzed by histone methyltransferases, which is a widely-studied mechanism of epigenetic regulation.
Methylation Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Methylation below!
For more information on how to use Laverne, please read the How to Guide.
We have 4195 products for the study of Methylation that can be applied to Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.