Citrullination: PTMs Bioinformatics

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Citrullination Bioinformatics

Citrullination, also referred to as deimination, is a type of post-translational modification (PTM). The process of citrullination involves the conversion of one or more Arginine amino acids into Citrulline. Peptidylarginine Deiminases (PADs) are enzymes that catalyze this PTM by replacing the aldimine functional group with a ketone group. Citrullination is an essential post-translational modification as it regulates gene expression and may play a role in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis.

Citrullination Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Citrullination below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1422 products for the study of Citrullination that can be applied to Western Blot, Chromatin Immunoprecipitation, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry from our catalog of antibodies and ELISA kits.

31310002

Rabbit Polyclonal
Species Human
Applications WB, ELISA

2 Publications
NBP2-02082
Western Blot: PADI4 Antibody (4H5) [NBP2-02082] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PAD4 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PAD4.Immunocytochemistry/Immunofluorescence: PADI4 Antibody (4H5) [NBP2-02082] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY PAD4.

Mouse Monoclonal
Species Human, Monkey
Applications WB, Flow, ICC/IF

NBP1-25966
Western Blot: Proteinase 3/Myeloblastin/PRTN3 Antibody [NBP1-25966] - Human PMN (peripheral blood mononuclear cells isolated from buffycoat; denatured, reduced) using Rabbit antibody to c-terminal region of Pr3 (Wegener autoantigen): whole serum at 1: 500 dilution; blocked with 1% LFDM for 15 minutes at room temperature with shake, primary antibody incubated for 15 minutes at room temperature, washed 3 times with PBST, 5 minutes each. Secondary antibody was also incubated for 15 minutes at room temperature.Immunocytochemistry/Immunofluorescence: Proteinase 3/Myeloblastin/PRTN3 Antibody [NBP1-25966] - Human PBMC were isolated and adjusted to 106 cells. Cells were fixed with 2% formaldehyde for 10 min at 37C. Washed twice with PBS before cytospin the cells onto microscope slides. Cells were blocked with PBS containing 1%BSA for 20 min at RT. Excess of blocking solution was removed and cells were then incubated with Rabbit Ab to c-terminal region of Pr3 (Wegener autoantigen): whole serum for 30 min at RT (diluted 1:100 in the blocking buffer). Washed 3X with PBS and incubated with anti-Rabbit Alexa 586 for further 30 min. Washed as before and nuclear counterstained with DAPI. Neutrophils and Monocytes, known to have PR3 are intensely stained by the Rabbit Ab to c-terminal region of Pr3 (Wegener autoantigen): whole serum.

Rabbit Polyclonal
Species Human
Applications WB, Flow, ICC/IF

1 Publication
NB300-223
Western Blot: Vimentin Antibody [NB300-223] - Western blot of crude extract of human embryonic kidney Hek293 cells stained with NB300-223, showing a single strong clean band at approx. 50kDa.Immunocytochemistry/Immunofluorescence: Vimentin Antibody [NB300-223] - View of mixed neuron/glial cultures stained with NB300-223 (green) and  rabbit antibody to GFAP antibody NB300-141(red). Vimentin is expressed alone in fibroblastic and endothelial cells, which are the flattened cells in the middle of the image which appear green. Astrocytes may express primarily GFAP, or GFAP and vimentin, and so appear red (GFAP only) or golden yellow (GFAP and Vimentin). In cells which express both GFAP and vimentin, the two protein assemble to produce heteropolymer filaments.

Chicken Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

18 Publications
H00003126-M01
Western Blot: HLA DRB4 Antibody (4C8) [H00003126-M01] - HLA-DRB4 monoclonal antibody (M01), clone 4C8. Analysis of HLA-DRB4 expression in human kidney.Immunohistochemistry-Paraffin: HLA DRB4 Antibody (4C8) [H00003126-M01] - Analysis of monoclonal antibody to HLA-DRB4 on formalin-fixed paraffin-embedded human tonsil. Antibody concentration 1 ug/ml.

Mouse Monoclonal
Species Human
Applications WB, ELISA, IHC-P

1 Publication
NBP2-45312
Immunohistochemistry-Paraffin: HLA DRB1 Antibody (SPM288) [NBP2-45312] - Human Tonsil stained with HLA-DRB Monoclonal Antibody (SPM288).

Mouse Monoclonal
Species Human, Monkey, Mouse (Negative)
Applications WB, Flow, IHC-P

NBP2-14093
Western Blot: HLA DRB5 Antibody [NBP2-14093] - Analysis in human cell line HDLM-2.Immunohistochemistry-Paraffin: HLA DRB5 Antibody [NBP2-14093] - Staining of human tonsil shows moderate cytoplasmic positivity in germinal center cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

H00003125-B02P
Western Blot: HLA DRB3 Antibody [H00003125-B02P] - Analysis of HLA-DRB3 expression in human liver.Flow Cytometry: HLA DRB3 Antibody [H00003125-B02P] - Analysis of negative control 293 cells (Black) and HLA-DRB3 expressing 293 cells (Green) using HLA-DRB3 purified mouse polyclonal antibody.

Mouse Polyclonal
Species Human
Applications WB, Flow

NBP1-91834
Western Blot: DHX40 Antibody [NBP1-91834] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells) Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells)Immunocytochemistry/Immunofluorescence: DHX40 Antibody [NBP1-91834] - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NB600-717
Western Blot: MBP Antibody (12) [NB600-717] - Mouse Brain Tissue lysate probed with Rat anti MBP.

Rat Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

12 Publications
AF5739
Western blot shows lysates of ME-180 human cervical epithelial carcinoma cell line, HT-2 mouse T cell line, and Rat-2 rat embryonic fibroblast cell line. PVDF membrane was probed with 0.5 µg/mL Goat Anti-Human/Mouse/Rat CSRP1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5739) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB

NBP2-32001
Western Blot: SQLE Antibody [NBP2-32001] - Lane 1: Marker  [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.  Lane 2: Human cell line RT-551Immunohistochemistry-Paraffin: SQLE Antibody [NBP2-32001] - Staining of human testis shows strong cytoplasmic positivity in Leydig cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

1 Publication
NB100-74413
Western Blot: ER alpha/NR3A1 Antibody (EVG F9) [NB100-74413] - Analysis of various whole cell lysates.Immunocytochemistry/Immunofluorescence: ER alpha/NR3A1 Antibody (EVG F9) [NB100-74413] - Analysis of Estrogen Receptor alpha using Anti-Estrogen Receptor alpha Monoclonal Antibody (EVG F9) shows staining in U251 Cells. Estrogen Receptor alpha staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Estrogen Receptor alpha at a dilution of 1:200 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated.

Mouse Monoclonal
Species Human, Mouse, Rabbit
Applications WB, ICC/IF, IHC

NBP1-87527
Immunohistochemistry-Paraffin: Filaggrin Antibody [NBP1-87527] - Staining of paraffin embedded human skin tissue using Filaggrin antibody. Image from verified customer review.Immunohistochemistry: Filaggrin Antibody [NBP1-87527] - Staining of human vulva/anal skin shows strong cytoplasmic positivity in superficial layer of squamous epithelium.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

     1 Review

NBP2-25147
Western Blot: Enolase 1 Antibody (253) [NBP2-25147] - Blot of Hela cell lysates. The antibody stains a single sharp band corresponing to Enolase 1 at about 47 kDa.Immunocytochemistry/Immunofluorescence: Enolase 1 Antibody (253) [NBP2-25147] - Rat 3T3 cells stained with NBP2-25147 (green) and counterstained with chicken polyclonal antibody to Vimentin NB300-223 (red) and DNA (blue). NBP2-25147 reveals strong cytoplasmic staining, while the Vimentin antibody reveals cytoplasmic intermediate filaments.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

MAB3428
Western blot shows lysates of Jurkat human acute T cell leukemia cell line, Daudi human Burkitt's lymphoma cell line, and Ramos human Burkitt's lymphoma cell line. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human Lyp Monoclonal Antibody (Catalog # MAB3428) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Lyp was detected in immersion fixed paraffin-embedded sections of human lymph node using 25 µg/mL Mouse Anti-Human Lyp Monoclonal Antibody (Catalog # MAB3428) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <A class=NoLineLink href=

Mouse Monoclonal
Species Human
Applications WB, IHC

     1 Review

1 Publication
AF7257
PADI2 was detected in immersion fixed paraffin-embedded sections of human Alzheimer's brain (cortex) using Sheep Anti-Human PADI2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7257) at 3 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <A class=NoLineLink href=

Sheep Polyclonal
Species Human
Applications IHC