Zymosan, TLR2 Ligand

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Zymosan, TLR2 Ligand [NBP2-26233] - Ligand activity of Zymosan. The NF-kB/SEAPorter/HEK 293 and TLR2/NFkB/SEAPorter/ HEK 293 cell line cell lines were plated in a 96-well plate at 5 x 10^4 cells/well for 16 h. Cells ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Func, In vitro, In vivo, LA

Order Details

Zymosan, TLR2 Ligand Summary

Description
Zymosan is a yeast cell wall derivative that is composed of b-glucans, mannans, mannoproteins and chitin. Zymosan is a known activator of TLR2, of which inflammatory responses to this particle are synergistically generated by collaboration with Dectin-1 and result in NF-kB-induced inflammatory cytokine production and phagocytosis1. Zymosan is also known to directly bind TLR2. Product Validation The data shows that Zymosan activated the TLR2 cells but not the control cells.

Applications/Dilutions

Application Notes
This product is useful for Activation of Toll-like Receptor 2 (TLR2).Stimulation of TLR2 has been reported with 1-10 ug/ml. Note: TLR2 activation at this range of concentrations of Zymosan has also been observed in our product validation tests, please see the image. Use in In vivo assay and Functional inhibition reported in scientific literature (PMID 25846753). Use in Ligand activation reported in scientific literature (PMID 25957979). Use in In vitro reported in scientific literature (PMID 27351455).
Publications
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NBP2-26233 in the following applications:

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 25957979)

Packaging, Storage & Formulations

Storage
Store at -20C in powder form. Store at -80C once reconstituted.
Buffer
The Zymosan suspension solution is insoluble and remains opaque. Resuspend the solution by vortexing right before use.
Reconstitution Instructions
Reconstitute with 50 mg Zymosan with 1 ml ethanol in a sterilized non-pyrogenic vial by vortexing to a final concentration of 50 mg/ml. When diluting further, use sterilized endotoxin-free water or PBS

Alternate Names for Zymosan, TLR2 Ligand

  • Zymosan, TLR2 Ligand

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.
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Publications for Zymosan, TLR2 Ligand (NBP2-26233)(3)

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FAQs for Zymosan, TLR2 Ligand (NBP2-26233). (Showing 1 - 1 of 1 FAQs).

  1. What is the aproximate molecular weight of the zymosan TLR2 Ligand, NBP2-26233?
    • Since Zymosan is a polymer and therefore can be variable (a range of molecular weights) based upon the number of subunits in the polymer. The base unit is about 15 kDa with 3 subunits A/B/C.

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