Zymosan, TLR2 Ligand [NBP2-26233] - Ligand activity of Zymosan. The NF-kB/SEAPorter/HEK 293 and TLR2/NFkB/SEAPorter/ HEK 293 cell line cell lines were plated in a 96-well plate at 5 x 10^4 cells/well for 16 h. Cells ...read more
Zymosan is a yeast cell wall derivative that is composed of b-glucans, mannans, mannoproteins and chitin. Zymosan is a known activator of TLR2, of which inflammatory responses to this particle are synergistically generated by collaboration with Dectin-1 and result in NF-kB-induced inflammatory cytokine production and phagocytosis1. Zymosan is also known to directly bind TLR2. Product Validation The data shows that Zymosan activated the TLR2 cells but not the control cells.
This product is useful for Activation of Toll-like Receptor 2 (TLR2).Stimulation of TLR2 has been reported with 1-10 ug/ml. Note: TLR2 activation at this range of concentrations of Zymosan has also been observed in our product validation tests, please see the image. Use in In vivo assay and Functional inhibition reported in scientific literature (PMID 25846753). Use in Ligand activation reported in scientific literature (PMID 25957979). Use in In vitro reported in scientific literature (PMID 27351455).
Read Publications using NBP2-26233 in the following applications:
Human reactivity reported in scientific literature (PMID: 25957979)
Packaging, Storage & Formulations
Store at -20C in powder form. Store at -80C once reconstituted.
To prepare a 50mg/ml stock solution, mix 50mg Zymosan with 1ml ethanol in a sterile non-pyrogenic vial by vortexing. For further dilution, use sterilized endotoxin-free water or PBS. The stock solution is insoluble and remains opaque. Vortex before use.
Alternate Names for Zymosan, TLR2 Ligand
Zymosan, TLR2 Ligand
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.
Publications for Zymosan, TLR2 Ligand (NBP2-26233)(5)
We have publications tested in 2 confirmed species: Human, Bacteria.
We have publications tested in 4 applications: Func, In vitro, In-vivo, LA.
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Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.