Z-FA-FMK Inhibitor

Product Discontinued

Z-FA-FMK Inhibitor Summary

• Immunogen: Z-Phe-Ala-FMK
• Details of Functionality: Mass Spec: M+1=387.0
  Chromatography: TLC:EtOAc: 4, Hex: 6, Single Spot, Rf:0.4
  H NMR: All functional groups are present

Applications/Dilutions

• Application Notes: Z-FA-FMK is an inhibitor of cathepsins B and L. Z-FA-FMK is designed for in vitro use as a cell permeable control for the effects of fluormethyl-ketone derivatives (FMKs) on caspase activity; it has been used as a negative control for FMK based inhibitors of caspases in a various studies
• Theoretical MW: 386 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Make a stock solution of 10 mM in high purity DMSO (>99.9%)

Alternate Names for Z-FA-FMK Inhibitor

• C21H23FN2O4
• Z-Phe-Ala fluoromethyl ketone

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Inhibitors are guaranteed for 1 year from date of receipt.

Publications for Z-FA-FMK Inhibitor (NBP2-29384)(1)

Publication using NBP2-29384

• Crisanti P, Leon A, Lim DM et al. Aspirin prevention of NMDA-induced neuronal death by direct protein kinase Czeta inhibition. J Neurochem. 2005-06-01 [PMID: 15935075]