Z-D(OMe)E(OMe)VD(OMe)-FMK (Caspase 3/7 Inhibitor)


There are currently no images for Z-D(OMe)E(OMe)VD(OMe)-FMK Inhibitor (NBP2-29396).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details


Order Details

Z-D(OMe)E(OMe)VD(OMe)-FMK (Caspase 3/7 Inhibitor) Summary

Formula: C30H41O12N4F
Molecular Weight: 668
Mass Spec: M+1=669.3.
Chromatography: EtOAc:9, Hex: 1, Single Spot, Rf:0.5


Application Notes
This inhibitor is designed as a methyl ester to facilitate cell permeability. If the intended use is on purified or recombinant enzymes, esterase should be added to generate the free carboxyl groups.

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
Form: White Solid
Make a stock solution of 20 mM in high purity DMSO (>99.9%).

Alternate Names for Z-D(OMe)E(OMe)VD(OMe)-FMK (Caspase 3/7 Inhibitor)

  • Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK
  • Z-D(OMe)E(OMe)VD(OMe)-FMK


Members of the caspase family play key roles in apoptosis and inflammation. Z-D(OMe)E(OMe)VD(OMe)-FMK (ZDEVD- FMK) is a cell-permeable caspase peptide inhibitor that irreversibly binds to the catalytic site of caspases proteases, and inhibits caspase-mediated apoptosis by preventing caspase activity (reviewed in 1-3). Caspase inhibitors, like Z-DEVD-FMK, with the peptide recognition sequence DEVD are potent inhibitors of caspase-3 and were first described as caspase-3 inhibitors. It is now known that caspase inhibitors with the peptide recognition sequence DEVD also inhibit other caspases, albeit at higher concentrations. However, Z-DEVD-FMK and other inhibitors with the DEVD peptide recognition sequence continue to be denoted as caspase-3 specific inhibitors by a number of sources. The Z-D(OMe)E(OMe)VD(OMe)-FMK (Z-DEVD-FMK) peptide is O-methylated in the P4, P3 and P1 positions providing enhanced stability and increased cell permeability. Z-DEVD-FMK is typically used in assays to inhibit apoptosis. Z-DEVD-FMK has been used in many different types of apoptosis assays and published extensively; for example, a PubMed search reveals over 300 references citing Z-DEVD-FMK between 1999 and 2003. Users may want to consult the literature for additional information regarding applications for Z-DEVD-FMK.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Inhibitors are guaranteed for 1 year from date of receipt.

Publications for Z-D(OMe)E(OMe)VD(OMe)-FMK Inhibitor (NBP2-29396) (0)

There are no publications for Z-D(OMe)E(OMe)VD(OMe)-FMK Inhibitor (NBP2-29396).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Z-D(OMe)E(OMe)VD(OMe)-FMK Inhibitor (NBP2-29396) (0)

There are no reviews for Z-D(OMe)E(OMe)VD(OMe)-FMK Inhibitor (NBP2-29396). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

View specific protocols for Z-D(OMe)E(OMe)VD(OMe)-FMK Inhibitor (NBP2-29396): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Z-D(OMe)E(OMe)VD(OMe)-FMK Inhibitor (NBP2-29396) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional Z-D(OMe)E(OMe)VD(OMe)-FMK Products

Blogs on Z-D(OMe)E(OMe)VD(OMe)-FMK

There are no specific blogs for Z-D(OMe)E(OMe)VD(OMe)-FMK, but you can read our latest blog posts.

Contact Information

Product PDFs

Review this Product

Be the first to review our Z-D(OMe)E(OMe)VD(OMe)-FMK (Caspase 3/7 Inhibitor) and receive a gift card or discount.