Yellow Fever Virus NS1 Antibody (994718) [Alexa Fluor® 700]

• Reactivity: V
• Applications: ELISA
• Clone: 994718
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

Yellow Fever Virus NS1 Antibody (994718) [Alexa Fluor® 700] Summary

• Immunogen: Human embryonic kidney cell HEK293­-derived Yellow Fever Virus NS1
  Gln780-His1134
  Accession # P03314
• Specificity: Detects Yellow Fever Virus NS1 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Yellow Fever Virus NS1 Antibody (994718) [Alexa Fluor® 700]

• Yellow Fever Virus NS1
• YFV NS1
• YFV_NS1
• YFV-NS1

Background

Yellow fever virus (YFV) non-structural protein 1 (NS1) is produced by yellow fever virus (YFV), a mosquito-borne flavivirus that is responsible for numerous epidemics of yellow fever disease with high fatality rates (1). Flavivirus NS1 is a multifunctional virulence factor. The glycosylated NS1 exists as a membrane‑associated dimer after translocation into the endoplasmic reticulum lumen, where it is essential for viral genome replication (2). The secreted hexamer NS1 is involved in immune evasion and pathogenesis; it is identified as a potential diagnostic marker for early detection of the virus infections (2). Mature viral YFV NS1 contains 352 amino acids (afa) and shares high structural similarity to other flavivirus NS1 proteins, such as DENV and ZIKV.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • P03314()