Varicella Zoster Virus Antibody (NCP-1) Summary
VZV Ellen Strain from VZV-infected monkey kidney cells (BSC-1).
Cell Membrane and Cytoplasmic
Reacts with VZV nucleocapsid protein of 155kDa.
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
20mM Sodium Phosphate (pH 9.0)
Immunogen affinity purified
- Immunocytochemistry/Immunofluorescence 1:10-1:2000
- Immunoprecipitation 1:10-1:500
Cross-reacts with Monkey.
Alternate Names for Varicella Zoster Virus Antibody (NCP-1)
- Envelope glycoprotein gI
- Glycoprotein IV
- HHV 3
- Human herpes virus 3
- Human herpesvirus 3
- Membrane glycoprotein gE
Varicella Zoster Virus (VZV), a member of the human herpes virus family, causes two distinct clinical manifestations: childhood chickenpox(Varicella) and shingles (zoster). Varicella is the outcome of the primary infection with VZV, whereas, zoster is the result of VZV reactivation from latently infected sensory ganglia which occurs predominantly in aging and immunosuppressed individuals. VZV is closely related to the herpes simplex viruses (HSV), sharing much genome homology. The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV, however there is no equivalent of HSV gD. VZV virons are spherical and 150-200 nm in diameter. Its lipid envelope encloses the nucleocapsid of 162 capsomeres arranged in a hexagonal form. Its DNA is a single linear, double strand molecule, 125,000 nt long. Glycoprotein E (gE), a 623 amino acid type I integral membrane protein, is expressed on plasma membranes and in the cytoplasm of VZV infected cells, where it is presumed to be present in the membranes of intracellular vesicles or organelles. VZV gE complexes with gI in the rough endoplasmic reticulum, and most gE exists in the form of gE to gI heterodimers in infected cells. VZV gE is also a predominant component of the virion envelope. The functions of gE, which is encoded by ORF68, are of particular interest because it has been demonstrated that ORF68 is essential for VZV replication. In contrast, the genes for gE proteins can be deleted from herpes simplex virus and pseudorabies virus, albeit with significant reductions in infectivity in cell culture and in animal models. Since the VZV genome does not encode a homologue of gD, VZV gE may have functions that are usually segregated between gD and gE, or the gE to gI complex, in other alphaherpesviruses.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
Publications for Varicella Zoster Virus Antibody (NB600-1248) (0)
There are no publications for Varicella Zoster Virus Antibody (NB600-1248).
By submitting your publication information earn gift cards and discounts for future purchases.
Reviews for Varicella Zoster Virus Antibody (NB600-1248) (0)
There are no reviews for Varicella Zoster Virus Antibody (NB600-1248).
By submitting a review earn points towards our Rewards Program.
- 250 points for product review
- 500 additional points for an image with your product review
- Double points (500) if you are the first to review this product
- Double points (1000) if you are the first to review this product with an image
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for Varicella Zoster Virus Antibody (NB600-1248) (0)
Other Available Formats
Additional Varicella Zoster Virus Antibody (NCP-1) Products
Blogs on Varicella Zoster Virus