Varicella Zoster Virus Antibody (5B7) [FITC] (NB100-64509)

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Product Details

Summary
Reactivity ViSpecies Glossary
Applications ICC/IF
Clone
5B7
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Order Details

Varicella Zoster Virus Antibody (5B7) [FITC] Summary

Immunogen
Varicella zoster virus, Ellen strain
Specificity
Specific for Varicella zoster virus. It produces fluorescence in both the nucleus and cytoplasm. It does not cross react with HSV1,2 or CMV.
Isotype
IgM
Clonality
Monoclonal
Host
Mouse
Purity
IgM purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000

Reactivity Notes

Viral

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS and 1.0% BSA
Preservative
0.05% Sodium Azide
Purity
IgM purified

Alternate Names for Varicella Zoster Virus Antibody (5B7) [FITC]

  • Envelope glycoprotein gI
  • Gi
  • Glycoprotein IV
  • GPIV
  • HHV 3
  • HHV3
  • HHV3gp39
  • Human herpes virus 3
  • Human herpesvirus 3
  • Membrane glycoprotein gE
  • VZV
  • VZVgE
  • VZVgI

Background

Varicella Zoster Virus (VZV), a member of the human herpes virus family, causes two distinct clinical manifestations: childhood chickenpox(Varicella) and shingles (zoster). Varicella is the outcome of the primary infection with VZV, whereas, zoster is the result of VZV reactivation from latently infected sensory ganglia which occurs predominantly in aging and immunosuppressed individuals. VZV is closely related to the herpes simplex viruses (HSV), sharing much genome homology. The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV, however there is no equivalent of HSV gD. VZV virons are spherical and 150-200 nm in diameter. Its lipid envelope encloses the nucleocapsid of 162 capsomeres arranged in a hexagonal form. Its DNA is a single linear, double strand molecule, 125,000 nt long. Glycoprotein E (gE), a 623 amino acid type I integral membrane protein, is expressed on plasma membranes and in the cytoplasm of VZV infected cells, where it is presumed to be present in the membranes of intracellular vesicles or organelles. VZV gE complexes with gI in the rough endoplasmic reticulum, and most gE exists in the form of gE to gI heterodimers in infected cells. VZV gE is also a predominant component of the virion envelope. The functions of gE, which is encoded by ORF68, are of particular interest because it has been demonstrated that ORF68 is essential for VZV replication. In contrast, the genes for gE proteins can be deleted from herpes simplex virus and pseudorabies virus, albeit with significant reductions in infectivity in cell culture and in animal models. Since the VZV genome does not encode a homologue of gD, VZV gE may have functions that are usually segregated between gD and gE, or the gE to gI complex, in other alphaherpesviruses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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ICC/IF Video Protocol

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