Varicella Zoster Virus Antibody (5B7) [FITC]

Images

 

Product Details

Summary
Product Discontinued
View other related Varicella Zoster Virus Primary Antibodies

Order Details


    • Catalog Number
      NB100-64509
    • Availability
      Product Discontinued

    Can't find what you are looking for? Use our Antibody Concierge Service & we will help you locate your antibody!

    Or feel free to contact us for alternative products.

Varicella Zoster Virus Antibody (5B7) [FITC] Summary

Immunogen
Varicella zoster virus, Ellen strain
Specificity
Specific for Varicella zoster virus. It produces fluorescence in both the nucleus and cytoplasm. It does not cross react with HSV1,2 or CMV.
Isotype
IgM
Clonality
Monoclonal
Host
Mouse
Purity
IgM purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
FITC
Buffer
PBS and 1.0% BSA
Preservative
0.05% Sodium Azide
Purity
IgM purified

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000

Reactivity Notes

Viral

Alternate Names for Varicella Zoster Virus Antibody (5B7) [FITC]

  • Envelope glycoprotein gI
  • Gi
  • Glycoprotein IV
  • GPIV
  • HHV 3
  • HHV3
  • HHV3gp39
  • Human herpes virus 3
  • Human herpesvirus 3
  • Membrane glycoprotein gE
  • VZV
  • VZVgE
  • VZVgI

Background

Varicella Zoster Virus (VZV), a member of the human herpes virus family, causes two distinct clinical manifestations: childhood chickenpox(Varicella) and shingles (zoster). Varicella is the outcome of the primary infection with VZV, whereas, zoster is the result of VZV reactivation from latently infected sensory ganglia which occurs predominantly in aging and immunosuppressed individuals. VZV is closely related to the herpes simplex viruses (HSV), sharing much genome homology. The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV, however there is no equivalent of HSV gD. VZV virons are spherical and 150-200 nm in diameter. Its lipid envelope encloses the nucleocapsid of 162 capsomeres arranged in a hexagonal form. Its DNA is a single linear, double strand molecule, 125,000 nt long. Glycoprotein E (gE), a 623 amino acid type I integral membrane protein, is expressed on plasma membranes and in the cytoplasm of VZV infected cells, where it is presumed to be present in the membranes of intracellular vesicles or organelles. VZV gE complexes with gI in the rough endoplasmic reticulum, and most gE exists in the form of gE to gI heterodimers in infected cells. VZV gE is also a predominant component of the virion envelope. The functions of gE, which is encoded by ORF68, are of particular interest because it has been demonstrated that ORF68 is essential for VZV replication. In contrast, the genes for gE proteins can be deleted from herpes simplex virus and pseudorabies virus, albeit with significant reductions in infectivity in cell culture and in animal models. Since the VZV genome does not encode a homologue of gD, VZV gE may have functions that are usually segregated between gD and gE, or the gE to gI complex, in other alphaherpesviruses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Varicella Zoster Virus Antibody (NB100-64509) (0)

There are no publications for Varicella Zoster Virus Antibody (NB100-64509).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Varicella Zoster Virus Antibody (NB100-64509) (0)

There are no reviews for Varicella Zoster Virus Antibody (NB100-64509). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for Varicella Zoster Virus Antibody (NB100-64509) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Varicella Zoster Virus Products

Blogs on Varicella Zoster Virus

There are no specific blogs for Varicella Zoster Virus, but you can read our latest blog posts.

Contact Information

Product PDFs

Review this Product

Be the first to review our Varicella Zoster Virus Antibody (5B7) [FITC] and receive a gift card or discount.