Vancomycin Antibody

Product Discontinued

Vancomycin Antibody Summary

• Immunogen: Vancomycin conjugated to Keyhole limpet Haemocyanin plus thyroglobulin.
• Specificity: NB100-62978 is specific for Vancomycin, a glycopeptide antibiotic derived from Amycolatopsis orientalis that acts by inhibiting cell wall biosynthesis and altering the permeability of the bacterial cell membrane. Vancomycin is regarded as an antibiotic of last resort as in high doses it can be toxic to the ears and kidneys, whilst in low doses hypersensitivity reactions may occur.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 5.0 mg/ml
• Purity: Protein G purified

Alternate Names for Vancomycin Antibody

• 1404-90-6
• vancomycin
• Vancomycinum

Background

Until recently, Vancomycin was one of the most powerful antibiotics that no bacterial cell had resistance to. Vancomycin is a very successful glycopeptide antibiotic, attacking the D alanyl D alanine component of the cell wall. By binding to the D alanyl D alanine component, Vancomycin is able to interrupt the normal cell wall formation. However, recently cells have achieved resistance to vancomycin. The reason that the resistance is so effective is that these cells have modified the D alanyl D alanine components of the cell wall into D alanyl D lactate components. Although this may sound easy, the actual process involves a series of five or more genes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.