Recombinant Human PVRIG Fc Chimera Protein, CF


When Recombinant Human PVRIG Fc Chimera (Catalog #9365-PV)is immobilized at 1 μg/mL, 100 μL/well, Recombinant Human Nectin‑2/CD112 (Catalog #2229-N2) binds with an ED50 of 0.4-2.4 μg/mL.

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Recombinant Human PVRIG Fc Chimera Protein, CF Summary

Human embryonic kidney cell, HEK293-derived PVRIG protein
Accession #
N-terminal Sequence
Thr41 & Glu43
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins


Theoretical MW
40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
51-57 kDa, reducing conditions

Packaging, Storage & Formulations

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 500 μg/mL in PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human PVRIG Fc Chimera Protein, CF

  • C7orf15
  • C7orf15MGC138295
  • CD112R
  • MGC104322
  • MGC138297
  • MGC2463
  • poliovirus receptor related immunoglobulin domain containing
  • Poliovirus receptor-related immunoglobulin domain-containing protein
  • transmembrane protein PVRIG


Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family (1). It is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. The intracellular domain contains two tyrosine residues, one within an ITIM-like motif that is a potential docking site for phosphatases (1). The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. The human PVRIG gene is preferentially expressed in lymphocytes, such as T cells and NK cells, but not in monocyte derived dendritic cells (1). PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells (1).
  1. Zhu, Y., (2016) J. Exp. Med. 213:167.

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