Recombinant Human PVRIG Fc Chimera Protein, CF

Images

 
When Recombinant Human PVRIG Fc Chimera (Catalog #9365-PV)is immobilized at 1 μg/mL, 100 μL/well, Recombinant Human Nectin‑2/CD112 (Catalog #2229-N2) binds with an ED50 of 0.4-2.4 μg/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Format
Carrier-Free

Order Details

Recombinant Human PVRIG Fc Chimera Protein, CF Summary

Source
Human embryonic kidney cell, HEK293-derived PVRIG protein
Accession #
N-terminal Sequence
Thr41 & Glu43
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins

Applications/Dilutions

Theoretical MW
40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
51-57 kDa, reducing conditions

Packaging, Storage & Formulations

Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 500 μg/mL in PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human PVRIG Fc Chimera Protein, CF

  • C7orf15
  • C7orf15MGC138295
  • CD112R
  • MGC104322
  • MGC138297
  • MGC2463
  • poliovirus receptor related immunoglobulin domain containing
  • Poliovirus receptor-related immunoglobulin domain-containing protein
  • PVRIG
  • transmembrane protein PVRIG

Background

Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family (1). It is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. The intracellular domain contains two tyrosine residues, one within an ITIM-like motif that is a potential docking site for phosphatases (1). The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. The human PVRIG gene is preferentially expressed in lymphocytes, such as T cells and NK cells, but not in monocyte derived dendritic cells (1). PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells (1).
  1. Zhu, Y., et.al. (2016) J. Exp. Med. 213:167.

Publications for PVRIG (9365-PV) (0)

There are no publications for PVRIG (9365-PV).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for PVRIG (9365-PV) (0)

There are no reviews for PVRIG (9365-PV). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

FAQs for PVRIG (9365-PV) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional Array Products

Blogs on PVRIG

There are no specific blogs for PVRIG, but you can read our latest blog posts.

Customers Who Bought This Also Bought

PVRIG Antibody
NBP2-13832

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Recombinant Human PVRIG Fc Chimera Protein, CF and receive a gift card or discount.

Bioinformatics

Uniprot