Recombinant Human PVRIG Fc Chimera Protein, CF Summary
Human embryonic kidney cell, HEK293-derived PVRIG protein
Thr41 & Glu43
|Structure / Form
| Protein/Peptide Type
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
51-57 kDa, reducing conditions
Packaging, Storage & Formulations
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitute at 500 μg/mL in PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Recombinant Human PVRIG Fc Chimera Protein, CF
- poliovirus receptor related immunoglobulin domain containing
- Poliovirus receptor-related immunoglobulin domain-containing protein
- transmembrane protein PVRIG
Human PVRIG (poliovirus
receptor related immunoglobulin domain-containing protein), also known as CD112
receptor (CD112R), is an approximately 34 kDa single
transmembrane protein in the poliovirus receptor-like
protein (PVR) family (1). It is composed of a single extracellular
IgV domain, one transmembrane domain, and a long intracellular domain. The
intracellular domain contains two tyrosine residues, one within an ITIM-like
motif that is a potential docking site for phosphatases (1). The extracellular domain sequence
of human and mouse PVRIG have approximately 65% similarity. The human PVRIG
gene is preferentially expressed in lymphocytes, such as T cells and NK cells,
but not in monocyte derived dendritic cells (1). PVRIG functions as a cell
surface receptor for Nectin-2/CD112, a cell surface protein that is widely
expressed on antigen-presenting cells and tumor cells. Disrupting the
PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is
a novel checkpoint for human T cells (1).
Zhu, Y., et.al. (2016) J. Exp. Med. 213:167.
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