Recombinant Human IL-37b/IL-1F7b Protein


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Recombinant Human IL-37b/IL-1F7b Protein Summary

Additional Information
rh IL-37 Isoform a (Catalog # 1975-IL) is also available!
Details of Functionality
Measured by its ability to enhance IL-18 BP inhibition of IL-18-induced IFN-gamma release by KG‑1 human acute myelogenous leukemia cells. Bufler, P. et al. (2002) PNAS 99:13723. The ED50 for this effect is 2.5-12.5 μg/mL.
E. coli-derived human IL-37b/IL-1F7b protein
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
19.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
25 kDa, reducing conditions
Read Publications using
7585-IL in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS and DTT with BSA as a carrier protein.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 200 μg/mL in PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-37b/IL-1F7b Protein

  • IL37b
  • IL-37b


Human Interleukin 1 family member 7 (IL-1F7), also named FIL-1 zeta, IL-37, IL-1H4, IL-1HL and IL-1RP1, is an anti-inflammatory member of the IL-1 cytokine family. IL-1F7 shares approximately 21%, 24%, and 30% aa sequence identity with mature IL-1 alpha, IL-1 beta and IL-1ra, respectively. Mouse IL-1F7 has not been reported, but human IL-1F7 is active on mouse cells. Five isoforms (IL-1F7a through e) are generated through alternative exon usage and have distinct expression profiles (1‑5). Like IL-1 alpha, IL-1 beta and IL-18, all of the IL-1F7 variants lack a typical signal peptide. The longest IL-1F7 transcript is the basis for the product offered here. This product, also referred to as IL-1F7b, or IL-1F7 isoform 1, is normally generated from a 218 amino acid (aa) proprotein that consists of a 45 aa propeptide plus a 173 aa mature region that is cleaved by caspase-1 to generate the 32 kDa mature form (aa 46-218) (6). IL-1F7 is up-regulated by inflammatory stimuli in peripheral blood mononuclear cells (7). Experimental overexpression of IL-1F7b in vivo limits the inflammatory response and protects mice from colitis and LPS-induced shock (7, 8). Both unprocessed and mature IL-1F7b can form homodimers in solution (6, 7). Although IL-1F7b will bind to IL-18 R alpha with low affinity, this has no effect on IL‑18 receptor activity (4, 6, 9). Alternatively, IL-1F7b will also bind to IL-18 BP, generating a complex that interacts with IL-18R beta. This has the effect of attenuating IL‑18 activity via the IL-18 receptor (9). IL-1F7b can also function intracellularly. Following LPS-induced cleavage of its propeptide, IL-1F7b associates with Smad3 and translocates to the nucleus. This results in a reduction of pro-inflammatory cytokine secretion (10).
  1. Smith, D.E. et al. (2000) J. Biol Chem 275:1169.
  2. Kumar S. et al. (2000) J. Biol Chem 275:10308.
  3. Busfield S.J. et al. (2000) Genomics 66:213.
  4. Pan, G. et al. (2000) Cytokine 13:1.
  5. Boraschi, D. et al. (2011) Eur. Cytokine Netw. 22:127.
  6. Kumar S. et al. (2002) Cytokine 18:61.
  7. Nold, M.F. et al. (2010) Nat. Immunol. 11:1014.
  8. McNamee, E.N. et al. (2011) Proc. Natl. Acad. Sci. USA 108:16711.
  9. Bufler, P. et al. (2002) Proc. Natl. Acad. Sci. USA 99:13723.
  10. Sharma, S. et al. (2008) J. Immunol. 180:5477.

Publications for IL-37b/IL-1F7b (7585-IL)(6)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Bioassay, Cell Culture, In Vivo.

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Showing Publications 1 - 6 of 6.
Publications using 7585-IL Applications Species
I Tsilioni, H Pantazopou, P Conti, SE Leeman, TC Theoharide IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder Proc. Natl. Acad. Sci. U.S.A., 2020;0(0):. 2020 [PMID: 32601180] (Bioassay, Human) Bioassay Human
I Tsilioni, AB Patel, H Pantazopou, S Berretta, P Conti, SE Leeman, TC Theoharide IL-37 is increased in brains of children with autism spectrum disorder and inhibits human microglia stimulated by neurotensin Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):. 2019 [PMID: 31591201] (Cell Culture, Human) Cell Culture Human
Interleukin-37 Enhances the Suppressive Activity of Naturally Occurring CD4(+)CD25(+) Regulatory T Cells Sci Rep, 2016;6(0):38955. 2016 [PMID: 27941849] (Bioassay, Mouse) Bioassay Mouse
Cavalli G, Koenders M, Kalabokis V, Kim J, Tan A, Garlanda C, Mantovani A, Dagna L, Joosten L, Dinarello C Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation. Rheumatology (Oxford), 0;55(12):2220-2229. 0 [PMID: 27567100] (In Vivo, Mouse) In Vivo Mouse
Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma Sci Rep, 2016;6(0):26757. 2016 [PMID: 27225603] (Bioassay, Human) Bioassay Human
Wang W, Zhao D, Zhou Y, Hu X, Sun Z, Yu G, Wu W, Chen S, Kuang J, Xu G, Han Z, Wang B, Yang J, Feng X Transfer of the IL-37b gene elicits anti-tumor responses in mice bearing 4T1 breast cancer. Acta Pharmacol Sin, 2015;36(4):528-34. 2015 [PMID: 25832432] (Bioassay, Mouse) Bioassay Mouse

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Gene Symbol IL37