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Radicicol Summary

Hsp90 inhibitor. Synthetic Radicicol, produced by fermentation. White to yellow solid.


Application Notes
Soluble in DMSO.

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.


Radicicol inhibits src (IC50 = 0.27 uM) and src-like kinases (1), leading to hypophosphorylation of retinoblastoma tumor suppressor protein (2). It causes morphological reversion of ras-transformed cells (3) and leads to selective depletion of Raf kinase (4). It also displays anti-angiogenic activity (5), and binds to and inhibits Hsp 90 molecular chaperone (6). It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1.

1. Kwon H.J., et al. (1992) Cancer Res. 52: 6929.
2. Yen A., et al. (1994) Exp.Cell Res. 214: 163.
3. Kwon H.J., et al. (1995) J.Biochem.(Tokyo) 118: 221.
4. Soga S., et al. (1998) J.Biol.Chem. 273: 822.
5. Oikawa T., et al. (1993) Eur.J.Pharmacol. 241: 221.
6. Roe S.M. et al. (1999) J.Med.Chem. 42: 260.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.

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