Parainfluenza Virus type 3 Antibody (341/7H (PAR3))

Product Discontinued

Parainfluenza Virus type 3 Antibody (341/7H (PAR3)) Summary

• Immunogen: Parainfluenza Virus 3 haemagglutinin protein.
• Specificity: NB100-63037 specifically recognizes an epitope within the haemagglutinin-neuraminidase (HN) protein of parainfluenza virus 3 (HPIV-3), an enveloped single-stranded RNA virus of the Paramyxoviridae family. Parainfluenza viruses are genetically and antigenically divided into the four types HPIV1-4, with HPIV-1, -2 and -3 being major causative agents of lower respiratory infections in the young and immunologically vulnerable. The HN protein of all HPIV, is a 69-82kDa surface glycoprotein which mediates the attachment of the virus to the host cell, through binding to cell surface sialic acid-containing receptors. The receptor-cleaving neuraminidase activity of HN is essential for further infection by HPIV, by ensuring the release of progeny virions.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.5)
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A or G purified

Background

Human parainfluenza viruses (HPIV) were first discovered in the late 1950s. HPIV is genetically and antigenically divided into types 1 to 4. HPIV 1 to HPIV 3 are major causes of lower respiratory infections in infants, young children, the immunocompromised, the chronically ill, and the elderly. Each subtype can cause somewhat unique clinical diseases in different hosts. HPIV are enveloped and of medium size (150 to 250 nm), and their RNA genome is in the negative sense. These viruses belong to the Paramyxoviridae family, one of the largest and most rapidly growing groups of viruses causing significant human and veterinary disease. HPIV are closely related to recently discovered megamyxoviruses (Hendra and Nipah viruses) and metapneumovirus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.