| Reactivity | MuSpecies Glossary |
| Applications | IP, B/N |
| Clone | 286828 |
| Clonality | Monoclonal |
| Host | Rat |
| Conjugate | Alexa Fluor 750 |
| Conjugate | Catalog # | Availability | Size | Price |
|---|---|---|---|---|
| Alexa Fluor 350 | FAB4288U-100UG | |||
| Alexa Fluor 405 | FAB4288V-100UG | |||
| Alexa Fluor 488 | FAB4288G-100UG | |||
| Alexa Fluor 532 | FAB4288X-100UG | |||
| Alexa Fluor 594 | FAB4288T-100UG | |||
| Alexa Fluor 647 | FAB4288R-100UG | |||
| Alexa Fluor 700 | FAB4288N-100UG | |||
| Unconjugated | MAB4288 | |||
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Mast Cell Protease‑6/Mcpt6 Ile32-Ser276 Accession # P21845 |
| Specificity | Detects mouse Mast Cell Protease‑6/Mcpt6 in direct ELISAs. |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Host | Rat |
| Purity Statement | Protein A or G purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied |
| Buffer | Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide |
Tryptases are trypsin-like serine proteases, and beta tryptases appear to be the main isoenzymes expressed in mast cells (1). Mast Cell Protease-6 (MCP-6, Mcpt6, or Tpsb2) is one of beta tryptases produced from mouse mast cells. It is stored in secretory granules of mast cells, where it forms active tetramers with heparin proteoglycan. Because of the unique arrangement of the active sites in the tetramer, which are facing a narrow central pore, MCP-6 is resistant to macromolecular protease inhibitors (2). When mast cells are activated, MCP-6 is released along with other proteins in secretory granules, participating in provoking inflammatory conditions (3). MCP-6 has been implicated as a mediator in the pathogenesis of asthma and other allergic disorders in mouse models.
Secondary Antibodies |
Isotype Controls |
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