LDL Uptake Assay Kit (Fluorometric)

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Product Details

Summary
Applications Func
Suitable Sample Type
Cultured Cells

Order Details

LDL Uptake Assay Kit (Fluorometric) Summary

Description
LDL Uptake Cell-Based Assay Kit is a tool for studying LDL uptake and regulation at the cellular level.
Assay Type
Fluorometric
Sample Volume
3 x 10^4 cells per well
Kit Type
Assay Kit (Fluorometric)

Packaging, Storage & Formulations

Storage
Storage of components varies. See protocol for specific instructions.

Kit Components

Components
  1. Rabbit Anti-LDL Receptor Primary Antibody
  2. DyLightTM 488-Conjugated Goat Anti- Rabbit IgG Secondary Antibody
  3. LDL-DyLightTM 550
  4. Cell-Based Assay Blocking Solution
  5. Cell-Based Assay Fixative

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Background

LDL is the major carrier of cholesterol in the blood, accounting for more than 60% of total plasma cholesterol. LDL is taken up by hepatic and extrahepatic tissues through receptor-mediated endocytosis triggered by apoB-100-LDL receptor interaction. The internalized LDL particle is transported to lysosomes where it is degraded to free cholesterol and amino acids. In humans, the liver is the most important organ for LDL catabolism and LDL receptor activity. In the liver, LDL can be regulated by pharmacologic intervention.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Kits are guaranteed for 6 months from date of receipt.

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Other Available Formats

Additional LDL Uptake Products

Array KA1327

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