LDL Uptake Assay Kit (Fluorometric)

• Applications: Func
• Suitable Sample Type: Cultured Cells

LDL Uptake Assay Kit (Fluorometric) Summary

• Description: LDL Uptake Cell-Based Assay Kit is a tool for studying LDL uptake and regulation at the cellular level.
• Assay Type: Fluorometric
• Sample Volume: 3 x 10^4 cells per well
• Kit Type: Assay Kit (Fluorometric)

Applications/Dilutions

• Dilutions:
  • Functional

Packaging, Storage & Formulations

• Storage: Storage of components varies. See protocol for specific instructions.

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Background

LDL is the major carrier of cholesterol in the blood, accounting for more than 60% of total plasma cholesterol. LDL is taken up by hepatic and extrahepatic tissues through receptor-mediated endocytosis triggered by apoB-100-LDL receptor interaction. The internalized LDL particle is transported to lysosomes where it is degraded to free cholesterol and amino acids. In humans, the liver is the most important organ for LDL catabolism and LDL receptor activity. In the liver, LDL can be regulated by pharmacologic intervention.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Kits are guaranteed for 6 months from date of receipt.

Publications for LDL Uptake Kit (KA1327)(4)

Publications using KA1327

• Yi J, Tianhui H, Jun Y et al. Resveratrol protects against postmenopausal atherosclerosis progression through reducing PCSK9 expression via the regulation of the ER?-mediated signaling pathway. Biochem Pharmacol. 2023-04-06 [PMID: 37030661]
• Hi-Jin Y, Hyung-Kyu K, Min-Sook K et al. Establishment and characterization of two human cutaneous angiosarcoma cell lines, KU-CAS3 and KU-CAS5. Head Neck. 2021-10-24 [PMID: 34693591]
• Mohammad J, Khadijeh M, Paul G et al. Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake. Methods Mol Biol. 2021-09-03 [PMID: 34473340]
• Jing Y, Hu T, Lin C et al. Resveratrol downregulates PCSK9 expression and attenuates steatosis through estrogen receptor ?-mediated pathway in L02 cells. Eur J Pharmacol. 2019-05-11 [PMID: 31085239]