IFN-lambda 4 Antibody (991620) [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Clone: 991620
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 594

IFN-lambda 4 Antibody (991620) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects human IFN-lambda 4 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-lambda 4 Antibody (991620) [Alexa Fluor™ Plus 594]

• IFNAN
• IFNL4
• IFNlambda 4
• IFN-lambda 4

Background

Interferon-lambda 4 (IFN-lambda 4) is a secreted, approximately 17 kDa member of the type III interferon family of molecules (1). It is generated by a frameshift mutation based on a TT > ∆G polymorphism (2). The TT allele inactivates expression of IFN-lambda 4 (2). The ∆G allele is associated with reduced clearance of hepatitis C virus and reduced degranulation of CTL, NK, and NKT cells in the liver during hepatitis (2, 3), although IFN- lambda 4 itself shows in vitro activity against hepatitis C virus (4). IFN-lambda 4 is expressed in the liver of some chronic hepatitis C patients (5). It signals through a receptor complex containing IL-28 R/IFN-lambda R1 and IL-10 R beta to induce the expression of several interferon stimulated genes (ISG) (2, 4). Alternative splicing generates additional isoforms with large internal deletions or a substituted C-terminal region.

1. Wack, A. et al. (2015) Nat. Immunol. 16:802.
2. Prokunina-Olsson, L. et al. (2013) Nat. Genet. 45:164.
3. Jouvin-Marche, E. et al. (2014) J. Infec. Dis. 209:1907.
4. Hamming, O.J. et al. (2013) EMBO J. 32:3055.
5. Amanzada, A. et al. (2013) PLoS One 8:e84026.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.