Human Neural Progenitor Cells (hNPCs)

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Human Neural Progenitor Cells (hNPCs) Summary

• Description: Advantages of hCCNs: 1. Human cells;
  2. High purity neural progenitor population;
  3. Ready-made, easy to maintain and differentiate;
  4. Robust enough to undergo genetic manipulation;
  5. Functional and molecular features extensively characterized;
  6. Capable of differentiating into an array of cortical neurons and astrocytes;
  7. Remain viable in culture for months to facilitate reproducible and long term studies;
  8. Available in industrial quantity;
  9. Cells from multiple donors (>6) are available for purchase allowing data comparison among biological replicates.
  
  
  This product is powered by Axol Bioscience Ltd.
• Background: This product is provided with the following additional items free of charge: Sure Boost ( TM ) Supplement: NBP2-31355 and Neural Advance ( TM ) Supplement: NBP2-31351
  
  hNPCs are derived from integration-free, induced pluripotent stem (iPS) cells under fully defined neural induction conditions. The hNPCs express typical markers of cerebral cortical neural stem and progenitor cells e....g. Pax6 and Foxg1, and spontaneously form polarized neural tube-like rosette structures when plated as a monolayer in culture. Additionally, hNPCs are capable of generating a spectrum of cortical neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. Cerebral cortical neurons are implicated in numerous neurological diseases including Alzheimer's disease, autism, epilepsy and stroke. Despite strong interest in these diseases, high quality human in vitro cell models for cortical neurophysiology were unavailable until now. With hNPCs, we provide neuroscience researchers with a high quality in vitro human system to complement their existing studies of cortical development, function and diseases using animal models.
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• Specificity: 1. Cell Type: Neural progenitors 2. Species: Human 3. Source: Human iPSCs (reprogrammed with episomal vectors; no gene insertion detected in the iPSCs) 4. Donor gender: Male 5. Donor age: Newborn 6. Karyotype: Normal 7. Quantity: 2 x 10^6 viable cells 8. Presentation: Cells are provided cryopreserved in 1 ml of freezing medium 9. Growth Properties: Adherent 10. Quality Assurance: Cells are negative for HIV, HBV, HCV, bacteria, mycoplasma and fungal contamination

Applications/Dilutions

• Application Notes: Applications Including but not limited to: 1. Studying Corticogenesis in vitro 2. Studying neural network formation and signal transmission 3. Disease modelling 4. Neurotoxicity testing 5. Preclinical drug efficacy testing 6. Research and development of cell therapies in animal models

Packaging, Storage & Formulations

• Storage: Store in gas phase of liquid nitrogen.

Alternate Names for Human Neural Progenitor Cells (hNPCs)

• hNPCs
• Neural Progenitor Cells (hNPCs)
• Progenitor Cells

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.