Human IL-29/IL-28B (IFN-lambda 1/3) DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-29/IL-28B (IFN-lambda 1/3) DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IFNL1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-29/IL-28B (IFN-lambda 1/3) DuoSet ELISA, 15 Plate

• IFNl1
• IFNl3
• IFNlambda 1
• IFNlambda 3
• IL-29/IL-28B (IFN-lambda 1/3)

Background

Human/mouse IL-28A (IFN-lambda 2), IL-28B (IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.

Publications for IL-29/IL-28B IFN-lambda 1/3) (DY1598B)(32)

Publications using DY1598B

• Reuschl, AK;Thorne, LG;Whelan, MVX;Ragazzini, R;Furnon, W;Cowton, VM;De Lorenzo, G;Mesner, D;Turner, JLE;Dowgier, G;Bogoda, N;Bonfanti, P;Palmarini, M;Patel, AH;Jolly, C;Towers, GJ; Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants Nature microbiology 2024-01-16 [PMID: 38228858] (Human)
• De, M;Sukla, S;Bharatiya, S;Keshri, S;Roy, DG;Roy, S;Dutta, D;Saha, S;Ejazi, SA;Ravichandiran, V;Ali, N;Chatterjee, M;Chinnaswamy, S; IFN-?3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans Infection and immunity 2024-01-09 [PMID: 38193711] (Human)
• Schutt, WR;Conde, JN;Mladinich, MC;Himmler, GE;Mackow, ER; ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFN?/? expression and promotes ZIKV persistence mBio 2023-09-14 [PMID: 37707056] (Human)
• Sugimoto, A;Numaguchi, T;Chihama, R;Takenaka, Y;Sato, Y; Identification of novel lactic acid bacteria with enhanced protective effects against influenza virus PloS one 2023-08-09 [PMID: 37556447] (Human)
• H Stölting, L Baillon, R Frise, K Bonner, RJ Hewitt, PL Molyneaux, ML Gore, Breathing, WS Barclay, S Saglani, CM Lloyd Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1 Mucosal Immunology, 2022-07-15;0(0):. 2022-07-15 [PMID: 35840680] (Human)
• A Steiner, K Hrovat-Sch, I Prigione, CH Yu, P Laohamonth, CR Harapas, RRJ Low, D De Nardo, LF Dagley, MJ Mlodzianos, KL Rogers, T Zillinger, G Hartmann, MP Gantier, M Gattorno, M Geyer, S Volpi, S Davidson, SL Masters Deficiency in coatomer complex I causes aberrant activation of STING signalling Nature Communications, 2022-04-28;13(1):2321. 2022-04-28 [PMID: 35484149] (Human)
• Y Song, G Hou, J Diep, YS Ooi, NS Akopyants, SM Beverley, JE Carette, HB Greenberg, S Ding Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation Nucleic Acids Research, 2021-12-16;0(0):. 2021-12-16 [PMID: 34791430] (Human)
• SJ Oh, OS Shin SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response Cells, 2021-03-02;10(3):. 2021-03-02 [PMID: 33801464] (Human)
• MR Hendricks, S Lane, JA Melvin, Y Ouyang, DB Stolz, JV Williams, Y Sadovsky, JM Bomberger Extracellular vesicles promote transkingdom nutrient transfer during viral-bacterial co-infection Cell Reports, 2021-01-26;34(4):108672. 2021-01-26 [PMID: 33503419] (Human)
• K Hjorton, N Hagberg, P Pucholt, ML Eloranta, L Rönnblom The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells Arthritis Res. Ther., 2020-06-05;22(1):130. 2020-06-05 [PMID: 32503683] (Human)
• J Alam, A Lee, J Lee, DI Kwon, HK Park, JH Park, S Jeon, K Baek, J Lee, SH Park, Y Choi Dysbiotic oral microbiota and infected salivary glands in Sj�gren's syndrome PLoS ONE, 2020-03-24;15(3):e0230667. 2020-03-24 [PMID: 32208441] (Human)
• H Xu, SJ Xu, SJ Xie, Y Zhang, JH Yang, WQ Zhang, MN Zheng, H Zhou, LH Qu MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway Elife, 2019-02-08;8(0):. 2019-02-08 [PMID: 30735121] (Human)
• M Niwa, T Fujisawa, K Mori, K Yamanaka, H Yasui, Y Suzuki, M Karayama, H Hozumi, K Furuhashi, N Enomoto, Y Nakamura, N Inui, T Suzuki, M Maekawa, T Suda IL-17A Attenuates IFN-? Expression by Inducing Suppressor of Cytokine Signaling Expression in Airway Epithelium J. Immunol., 2018-09-17;0(0):. 2018-09-17 [PMID: 30224514] (Human)
• F Colavita, V Bordoni, C Caglioti, M Biava, C Castillett, L Bordi, S Quartu, M Iannetta, G Ippolito, C Agrati, MR Capobianch, E Lalle ZIKV Infection Induces an Inflammatory Response but Fails to Activate Types I, II, and III IFN Response in Human PBMC Mediators Inflamm., 2018-06-03;2018(0):2450540. 2018-06-03 [PMID: 29967565] (Human)
• S Ding, J Diep, N Feng, L Ren, B Li, YS Ooi, X Wang, KF Brulois, LL Yasukawa, X Li, CJ Kuo, DA Solomon, JE Carette, HB Greenberg STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection Nat Commun, 2018-04-16;9(1):1485. 2018-04-16 [PMID: 29662124] (Human)
• N Ueno, N Nishimura, S Ueno, S Endo, H Tatetsu, S Hirata, H Hata, M Matsuoka, H Mitsuya, Y Okuno PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF4 Oncogene, 2017-04-03;0(0):. 2017-04-03 [PMID: 28368411] (Human)
• Charlene Akoto Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations Clin. Exp. Allergy, 2017-01-26;0(0):. 2017-01-26 [PMID: 28008678] (Human)
• Luminita A Stanciu Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro Antiviral Res., 2016-11-10;0(0):. 2016-11-10 [PMID: 27838350] (Human)
• Lalle E, Bordi L, Caglioti C, Garbuglia A, Castilletti C, Taibi C, Cristofari F, Capobianchi M IFN-Alpha receptor-1 upregulation in PBMC from HCV naive patients carrying cc genotype. possible role of IFN-lambda. PLoS ONE, 2014-04-01;9(4):e93434. 2014-04-01 [PMID: 24691098] (Human)
• Dolganiuc A, Kodys K, Marshall C, Saha B, Zhang S, Bala S, Szabo G Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells. PLoS ONE, 2012-10-10;7(10):e44915. 2012-10-10 [PMID: 23071503] (Human)
• Yin Z, Dai J, Deng J, Sheikh F, Natalia M, Shih T, Lewis-Antes A, Amrute S, Garrigues U, Doyle S, Donnelly R, Kotenko S, Fitzgerald-Bocarsly P Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells. J Immunol, 2012-08-13;189(6):2735-45. 2012-08-13 [PMID: 22891284] (Human)
• Bierne H, Travier L, Mahlakoiv T, Tailleux L, Subtil A, Lebreton A, Paliwal A, Gicquel B, Staeheli P, Lecuit M, Cossart P Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta. PLoS ONE, 2012-06-14;7(6):e39080. 2012-06-14 [PMID: 22720036] (Human)
• Popugaeva E, Witkowski PT, Schlegel M, Ulrich RG, Auste B, Rang A, Kruger DH, Klempa B Dobrava-Belgrade hantavirus from Germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans. PLoS ONE, 2012-04-24;7(4):e35587. 2012-04-24 [PMID: 22545121] (Primate)
• Donnelly , O G, Errington-Mais , F, Steele , L, Hadac , E, Jennings , V, Scott , K, Peach , H, Phillips , R M, Bond , J, Pandha , H, Harrington , K, Vile , R, Russell , S, Selby , P, Melcher , A A Measles virus causes immunogenic cell death in human melanoma. Gene Ther, 2011-12-15;20(1):7-15. 2011-12-15 [PMID: 22170342] (Human)
• Sancho-Shimizu V, Perez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, Fabrega S, Cardon A, Maluenda J, Tatematsu M, Mahvelati F, Herman M, Ciancanelli M, Guo Y, AlSum Z, Alkhamis N, Al-Makadma AS, Ghadiri A, Boucherit S, Plancoulaine S, Picard C, Rozenberg F, Tardieu M, Lebon P, Jouanguy E, Rezaei N, Seya T, Matsumoto M, Chaussabel D, Puel A, Zhang SY, Abel L, Al-Muhsen S, Casanova JL Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. J. Clin. Invest., 2011-11-21;121(12):4889-902. 2011-11-21 [PMID: 22105173] (Human)
• Zahn S, Rehkamper C, Kummerer BM, Ferring-Schmidt S, Bieber T, Tuting T, Wenzel J Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFN-lambda) in cutaneous lupus erythematosus. J. Invest. Dermatol., 2010-08-19;131(1):133-40. 2010-08-19 [PMID: 20720564] (Human)
• Pietila TE, Latvala S, Osterlund P, Julkunen I Inhibition of dynamin-dependent endocytosis interferes with type III IFN expression in bacteria-infected human monocyte-derived DCs. J. Leukoc. Biol., 2010-07-07;88(4):665-74. 2010-07-07 [PMID: 20610797] (Human)
• Stoltz M, Klingstrom J Alpha/beta interferon (IFN-alpha/beta)-independent induction of IFN-lambda1 (interleukin-29) in response to Hantaan virus infection. J. Virol., 2010-06-30;84(18):9140-8. 2010-06-30 [PMID: 20592090] (Human)
• Krausgruber T, Saliba D, Ryzhakov G IRF5 is required for late-phase TNF secretion by human dendritic cells. Blood, 2010-03-17;115(22):4421-30. 2010-03-17 [PMID: 20237317] (Human)
• Megjugorac NJ, Gallagher GE, Gallagher G IL-4 enhances IFN-lambda1 (IL-29) production by plasmacytoid DCs via monocyte secretion of IL-1Ra. Blood, 2010-03-16;115(21):4185-90. 2010-03-16 [PMID: 20233967] (Human)
• Wang Q, Nagarkar DR, Bowman ER, Schneider D, Gosangi B, Lei J, Zhao Y, McHenry CL, Burgens RV, Miller DJ, Sajjan U, Hershenson MB Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J. Immunol., 2009-11-04;183(11):6989-97. 2009-11-04 [PMID: 19890046] (Human)
• Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. J. Leukoc. Biol., 2008-02-15;83(5):1181-93. 2008-02-15 [PMID: 18281438] (Human)

Bioinformatics

• Gene Symbol: IFNL1