| Clone | 462510 |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugate | Alexa Fluor Plus 680 |
| Specificity | Detects viral HHV8-ORF74. |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Host | Mouse |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied |
| Buffer | Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide. |
HHV8‑ORF74 is a 342 amino acid viral 7-transmembrane receptor encoded by the Kaposi's sarcoma-associated herpesvirus 8. The G‑protein-coupled receptor is a constitutively active homologue of CXCR2, the CXCL8 receptor (IL-8 RB). It contributes to Kaposi's sarcoma by triggering expression of paracrine factors such as VEGF-A, inflammatory cytokines, adhesion molecules and chemokines, and enhancing cell growth.
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