Herpes Simplex Virus 1 Antibody (B007 (LP2))

Product Discontinued

Herpes Simplex Virus 1 Antibody (B007 (LP2)) Summary

• Immunogen: HSV 1 strains HFEM and SC16. HSV 2 strains 333 and 25766.
• Specificity: NB100-64689 specifically recognizes an epitope within glycoprotein D of Herpes Simplex Virus (HSV) type 1 and type 2. Glycoprotein D (gD) is a viral envelope component also expressed in the membranes of HSV infected cells, and is known to be a principle immunogen of infected humans and a major target for the neutralisation of infecting viruses. Clone B007 (LP2) has been shown to efficiently neutralise HSV type 1 and type 2. NB100-64689 can be used as an ELISA pair in conjunction with clone AP7, which recognizes a different gD epitope.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:100

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A or G purified

Alternate Names for Herpes Simplex Virus 1 Antibody (B007 (LP2))

• Herpes simplex virus 1
• Herpes simplex virus type 1
• Herpes simplex virus
• HSV 1
• Human herpesvirus 1
• Human herpesvirus type 1

Background

Herpes simplex type 1 (HSV-1) belongs to a family that includes HSV-2, Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus amongst others. HSV-1 and HSV-2 are extremely difficult to distinguish from each other. Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope, derived from the nuclear membrane of the last host, which is decorated with virus-specific glycoproteins spikes. These viruses are capable of entering a latent phase where the host shows no visible sign of infection and levels of infectious agent become very low. During the latent phase the viral DNA is integrated into the genome of the host cell.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.